Evaporative light scattering detector
An improved evaporative light scattering detector apparatus for volatile samples is provided. Conventionally incomplete evaporation of the mobile phase (solvent) cannot be achieved for volatile samples as solvent cannot be fully removed at low temperature because the vapor becomes saturated. At higher temperatures the samples evaporate without forming an aerosol. By adding a dry evaporator gas to the sample before entering a drift tube avoids saturation of the vapor and permits complete evaporation of the solvent at low temperatures.
1. A light scattering detection apparatus comprising:
a nebulizer having a first inlet port for receiving chromatographic eluent with sample material and solvent, and a second inlet port for receiving nebulizing gas, said nebulizer producing primary aerosol of different size droplets from said eluent;
a nebulization chamber coupled to said nebulizer for receiving the primary aerosol of different size droplets and nebulizing gas and for separating droplets of primary aerosol into larger and smaller sizes of droplets partially drying thereof, the droplets of smaller sizes and the nebulizing gas forming a secondary aerosol; and
a drift tube having a first inlet port connected to the nebulization chamber for receiving the secondary aerosol, and a second inlet port for receiving an evaporator gas into the drift tube for mixing with the secondary aerosol, wherein the evaporator gas allows for drying of the secondary aerosol by evaporating a solvent from the droplets to form a tertiary aerosol of dried aerosol droplets.
2. The light scattering detection apparatus as claimed in claim 1 , wherein said nebulization chamber provides an impact region for removing the larger droplets from said primary aerosol produced by the nebulizer.
3. The light scattering detection apparatus as claimed in claim 2 , wherein said nebulization chamber contains a waste port for the removal of said larger droplets from the nebulization chamber.
4. The light scattering detection apparatus as claimed in claim 1 , wherein said nebulization chamber provides heating means to control its temperature.
5. The light scattering detection apparatus as claimed in claim 1 , wherein said evaporator gas is nitrogen.
6. The light scattering detection apparatus as claimed in claim 1 , wherein said evaporator gas is less than saturated with vapor.
7. The light scattering detection apparatus as claimed in claim 1 , wherein the evaporator gas is introduced substantially downstream from the nebulizer.
8. The light scattering detection apparatus as claimed in claim 1 , wherein means are provided to cool the drift tube.
9. The light scattering detection apparatus as claimed in claim 1 , wherein means are provided to heat the drift tube.
10. The light scattering detection apparatus as claimed in claim 1 , wherein the evaporator gas is introduced into the secondary aerosol after the nebulization chamber.
11. The light scattering detection apparatus as claimed in claim 1 , wherein the evaporator gas is introduced into the secondary aerosol after any post nebulization impactors.
12. The light scattering detection apparatus as claimed in claim 1 , wherein the evaporator gas is introduced into the secondary aerosol after any bends or chambers designed into the apparatus, whish act as ballistic traps.
13. The light scattering detection apparatus as claimed in claim 1 , wherein the evaporator gas is introduced into the secondary aerosol before complete evaporation of the solvent.
14. The light scattering detection apparatus as claimed in claim 1 , which further comprises optical detection means for detection of an incident light beam scattered by solute particles, particles in the tertiary aerosol.
15. The light scattering detection apparatus as claimed in claim 1 , is a detector utilized in chromatography of chemical moieties or mixtures thereof or particles or mixtures thereof.
16. The light scattering detection apparatus as claimed in claim 1 , is a detector utilized for continuous monitoring of particles in liquids.
17. The light scattering detection apparatus as claimed in claim 1 , further comprising a cooled drift tube.