Stabilized preparation containing protein
Protein formulations containing a poloxamer as a surfactant, and methods for maintaining the biological activity in protein formulations without adding an antioxidant and for inhibiting the formation of foreign insoluble matters by adding a poloxamer as a surfactant.
1. A protein formulation in the form of a solution, consisting of an immunoglobulin, a poloxamer as a surfactant, an acetate buffer, and optionally one or more free amino acids.
2. The protein formulation of claim 1 wherein the poloxamer is poloxamer 188.
3. The protein formulation of claim 1 wherein the immunoglobulin is a humanized antibody.
4. The protein formulation of claim 1 wherein the immunoglobulin is an anti-tissue factor antibody.
5. The protein formulation of claim 4 wherein the anti-tissue factor antibody is a humanized anti-tissue factor antibody.
6. The protein formulation of claim 1 which includes one or more free amino acids.
7. The protein formulation of claim 1 which does not include free amino acids.
8. The protein formulation of claim 1 which does not include an anti-oxidant.