Anti-cancer virus desensitization method
A mammalian subject having a tumor is treated by a method comprising administering to the subject an amount of a Newcastle disease virus effective to treat the subject, wherein the virus is administered to the subject in one or more cycles; at least one cycle comprises administering sequentially one or more desensitization doses of the followed by one or more escalated doses of the virus to the subject; the amount of the virus in each escalated dose is higher than the amount of virus in each desensitization dose; and the first escalated dose is administered from 18 to 36 hours after the first desensitization dose.
1 . A method for treating a mammalian subject having a tumor, comprising administering to the subject an amount of a Newcastle disease virus effective to treat the subject, wherein
the virus is administered to the subject in one or more cycles;
at least one cycle comprises administering sequentially one or more desensitization doses of the followed by one or more escalated doses of the virus to the subject;
the amount of the virus in each escalated dose is higher than the amount of virus in each desensitization dose; and
the first escalated dose is administered from 18 to 36 hours after the first desensitization dose.
2 . The method of claim 1 , wherein the first escalated dose is administered from 24 to 36 hours after the first desensitization dose.
3 . The method of claim 1 , wherein the virus is a mesogenic strain of Newcastle Disease Virus.
4 . The method of claim 1 , wherein the virus is administered systemically.
5 . The method of claim 4 , wherein the virus is administered intravenously.
6 . The method of claim 5 , wherein the virus administered is a mesogenic strain of Newcastle Disease Virus.
7 . The method of claim 1 , wherein the virus dose is administered over an administration time period of up to 24 hours; and the dose is administered at a rate of up to 7.0×10 8 PFU per square meter of patient surface area in any ten minute sampling time period within the administration time period.
8 . The method of claim 7 , wherein the rate is up to 2.0×10 8 PFU per square meter of patient surface area in any ten minute sampling time period within the administration time period.
9 . The method of claim 7 , wherein the administration time period is at least 1 hour.
10 . The method of claim 9 , wherein the administration time period is at least 3 hours.
11 . The method of claim 1 , wherein the subject is a human subject.
12 . The method of claim 1 , wherein the subject is a non-human mammal.
13 . The method of claim 1 , wherein the size of the tumor decreases after administration of the virus.