Prophylactic pretreatment with antioxidants
Methods, compositions, and uses for pre-treating patients who are susceptible to ischemia, including stroke, with nitroxides, in order to prevent or ameliorate the effects of stroke or other ischemic disease.
1 . A method of treatment, comprising:
identifying a human patient that is susceptible to ischemia; and
administering a sufficient amount of a nitroxide to prevent a harmful effect of ischemia in the human patient prior to the onset of ischemia.
2 . The method of claim 1 , wherein the nitroxide is 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl.
3 . The method of claim 1 , wherein the human patient's susceptibility to ischemia arises from a medical procedure associated with a significant ischemic risk.
4 . The method of claim 3 , wherein the medical procedure is the treatment of a hemorrhage.
5 . The method of claim 3 , wherein the medical procedure is the treatment of an aneurysm.
6 . The method of claim 5 , wherein the medical procedure is surgery.
7 . The method of claim 5 , wherein the medical procedure is an endovascular procedure.
8 . The method of claim 1 , wherein the mode of nitroxide administration is selected from the group consisting of oral and intravenous administration.
9 . A method of treatment comprising:
identifying a patient scheduled to undergo a medical procedure involving a significant risk of ischemia;
administering to the patient, prior to the medical procedure, a prophylactic amount of nitroxide;
performing the medical procedure; and
administering to the patient, a prophylactic or therapeutic amount of nitroxide to ameliorate a harmful effect of ischemia.
10 . The method of claim 9 , wherein the nitroxide is 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl.
11 . The method of claim 9 , wherein the medical procedure is the treatment of a hemorrhage.
12 . The method of claim 9 , wherein the medical procedure is the treatment of an aneurysm.
13 . The method of claim 9 , wherein the medical procedure is surgery.
14 . The method of claim 9 , wherein the medical procedure is an endovascular procedure.
15 . The method of claim 9 , wherein the mode of nitroxide administration is selected from the group consisting of oral and intravenous administration.
16 . Use of a nitroxide in the preparation of a medicament to prevent a harmful effect of ischemia through administration to a mammalian patient prior to the onset of ischemia.
17 . The use of claim 16 , wherein the nitroxide is 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl.
18 . The use of claim 16 , wherein the patient's susceptibility to ischemia arises from a medical procedure associated with a significant ischemic risk.
19 . The use of claim 18 , wherein the medical procedure is the treatment of a hemorrhage.
20 . The use of claim 18 , wherein the medical procedure is the treatment of an aneurysm.
21 . The use of claim 20 , wherein the medical procedure is surgery.
22 . The use of claim 20 , wherein the medical procedure is an endovascular procedure.
23 . The use of claim 16 , wherein the mode of administration is selected from the group consisting of oral and intravenous administration.
24 . A medicament for preventing a harmful effect of ischemia through administration to a patient prior to the onset of ischemia, wherein the medicament comprises a nitroxide.
25 . The medicament of claim 24 , wherein the nitroxide is 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl.
26 . The medicament of claim 24 , wherein the patient has susceptibility to ischemia arising from a medical procedure associated with a significant ischemic risk.
27 . The medicament of claim 26 , wherein the medical procedure is the treatment of hemorrhage.
28 . The medicament of claim 26 , wherein the medical procedure is the treatment of an aneurysm.
29 . The medicament of claim 28 , wherein the medical procedure is surgery.
30 . The medicament of claim 28 , wherein the medical procedure is an endovascular procedure.
31 . The medicament of claim 24 , wherein the mode of administration is selected from the group consisting of oral and intravenous administration.