Antisense oligonucleotide having anticancerous activity
An antisense oligonucleotide having anti-carcinogenicity, for example, an inhibitory action on growth of cancer cells and a therapeutic or prophylactic action on cancer and the like, as well as an inhibitor of cancer cell growth and a therapeutic or prophylactic agent for cancer, which comprise the antisense oligonucleotide are provided. An antisense oligonucleotide to a nucleotide sequence of positions 47 to 51 of 7SL RNA of the signal recognition particle (SRP), an inhibitor of cancer cell growth comprising the antisense oligonucleotide, and a therapeutic or prophylactic agent for cancer comprising the antisense oligonucleotide.
1. An antisense oligonucleotide to a nucleotide sequence of positions 47 to 51 of 7SL RNA of a signal recognition particle (SRP), wherein said antisense oligonucleotide consists of the nucleotide sequence of SEQ ID NO: 1.
2. An inhibitor of cancer cell growth comprising the antisense oligonucleotide as defined in claim 1 .
3. A therapeutic or prophylactic agent for cancer comprising the antisense oligonucleotide as defined in claim 1 .
4. The therapeutic or prophylactic agent according to claim 3 , wherein the antisense oligonucleotide is present in a liposome.
5. A method for preparing a pharmaceutical composition comprising mixing the antisense oligonucleotide according to claim 1 with a pharmaceutically acceptable carrier.