Antibiotic compounds
View Patent ↗Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structure (I).
1. An isolated compound of structural formula (I):
or a pharmaceutically acceptable salt thereof.
2. A process for the preparation of an isolated compound of structural formula (I):
which comprises the cultivation of a Streptomyces sp. with ATCC# PTA-5316 (MA7327) or ATCC#PTA-5317 (MA7331) or a natural mutant thereof in a nutrient medium and isolating the Compound (I) from the fermentation broth.
3. The process of claim 2 wherein the fermentation is conducted at a temperature of about 10° C. to about 40° C.
4. The process of claim 3 , wherein the fermentation is conducted at a temperature of about 28° C.
5. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of a compound of structure (I) according to claim 1 .