Pharmaceutical compositions comprising ascorbic acid for the treatment of fungal superinfections and fungal recurrences
Method for prevention and treatment of vaginal fungal infections by administering a formulation comprising ascorbic acid or a physiologically acceptable salt thereof to a patient in need of such prevention or treatment. The formulation is administered after completion of the standard treatment against bacterial, fungal or protozoarian infections.
1. A method for the treatment of a vaginal fungal infection which comprises administering a topical formulation comprising an effective amount of ascorbic acid to a patient in need of such a treatment wherein said formulation is vaginally administered after completion of a standard treatment against bacterial, fungal or protozoarian infections.
2. The method according to claim 1 , wherein said formulation is administered after completion of a standard treatment with one or more antimicrobial agents.
3. The method according to claim 2 , wherein said antimicrobial agents are selected from the group consisting of antibacteric/antibiotics, antitrichomonas, and antifungal agents.
4. The method according to claim 2 , wherein said antimicrobial agents are selected from the group consisting of miconazole and metronidazole.
5. The method according to claim 1 , wherein said formulation has an ascorbic acid content of from 0.1 to 25%, with respect to the total weight of the formulation.
6. The method according to claim 5 , wherein said formulation has an ascorbic content of from 0.5 to 15% with respect to the total weight of the formulation.
7. The method according to claim 1 , wherein said fungal infection is a recurrence.
8. The method according to claim 1 , wherein said fungal infection is a superinfection.
9. The method according to claim 1 , wherein said fungal infection is caused by Candida albicans.
10. The method according to claim 1 , wherein said fungal infection is caused by Dermatophytes.
11. The method according to claim 1 , wherein ascorbic acid is the only active ingredient contained in the formulation.
12. The method according to claim 1 , wherein said formulation comprises additives selected from the group consisting of excipients and adjuvants.
13. The method according to claim 1 , wherein ascorbic acid is contained in the formulation in unitary dosages suitable for its application from 10 to 500 mg/day.
14. The method according to claim 1 , wherein said formulation is in a form suitable for application to external genitals, intertriginous areas, or for insertion into the vagina.
15. The method according to claim 1 , wherein said formulation is in the form of a cream, ointment, gel, lotion, or foam for vaginal application, tablets, pessaries, capsules for vaginal application, a form for delayed melting or a form for prolonged release of said ascorbic acid.
16. Method according to claim 6 , wherein said formulation has an ascorbic acid content of from 1.0 to 10% with respect to the total weight of the formulation.