Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors
Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R 1 , m, X, R 2 , n, W, p, Y, Z, R 3 , R 4 , R 5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.
1. 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone of formula (I) or a pharmaceutically acceptable salt thereof
2. A method of treatment of depression or anxiety in a mammal in need thereof, which comprises administering to said mammal a therapeutically effective amount of the compound as claimed in claim 1 .
3. A pharmaceutical composition comprising the compound as claimed in claim 1 , and a pharmaceutically acceptable carrier or excipient.
4. A process for preparing the pharmaceutical composition as defined in claim 3 , the process comprising mixing the compound and the pharmaceutically acceptable carrier or excipient.