Glycopeptide composition with improved antibiotic activity
A glycopeptide composition with improved antibiotic activity is disclosed, along with a method of preparing such a composition and a pharmaceutical composition made therefrom.
1. A pharmaceutical vancomycin antibiotic composition comprising
A: a vancomycin antibiotic in its glycosylated form; and
B: aglucovancomycin;
the content of B being 11% to 60% (w/w) of the total content of glycopeptides and deglycosylated glycopeptides, calculated as: B/(A+B) (w/w),
and a pharmaceutically acceptable carrier or excipient.
2. A pharmaceutical composition comprising a pharmaceutically acceptable amount of the composition according to claim 1 ; and a pharmaceutically acceptable carrier.
3. The composition of claim 1 , wherein the content of B is 20% to 60%.
4. The composition of claim 1 , wherein the content of B is 25% to 55%.
5. The composition of claim 1 , wherein the content of B is 11% to 55%.
6. A unit dosage form for pharmaceutical use, comprising a vancomycin antibiotic composition which comprises:
A: a vancomycin antibiotic in its glycosylated form; and
B: aglucovancomycin;
the content of B being 11% to 60% (w/w) of the total content of glycopeptides and deglycosylated glycopeptides, calculated as: B/(A+B) (w/w),
and a pharmaceutically acceptable carrier or excipient.