Agent for skin external use containing salt of ascorbic acid derivative, method for stabilizing the agent for skin external use, and stabilizer
View Patent ↗An agent for skin external use of the invention contains a salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester and a polyhydric alcohol. According to the present invention, occurrence of turbidity or precipitation with time can be prevented to enhance stability even when the agent for skin external use is prepared using a specific salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester. Therefore, the present invention is useful for all agents for skin external use, particularly cosmetics.
1. An agent for skin external use, comprising:
a salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester in an amount of 0.01 to 20% by mass, said higher fatty acid ester of ascorbic acid-2-phosphoric acid ester of the following formula (1):
wherein R is a residual group of an aliphatic carboxylic acid having 10 to 20 carbon atoms, and 1,2-pentanediol or 1,2-hexanediol in an amount of 0.05 to 12% by mass.
2. The agent for skin external use as claimed in claim 1 , wherein R in the formula (1) is a residual group of lauric acid, myristic acid, palmitic acid, stearic acid, 2-hexyldecanoic acid or isostearic acid.
3. The agent for skin external use as claimed in claim 1 , wherein R in the formula (1) is a residual group of palmitic acid.
4. The agent for skin external use as claimed in claim 1 , wherein R in the formula (1) is a residual group of 2-hexyldecanoic acid.
5. The agent for skin external use as claimed in claim 1 , wherein the salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester is a Na salt, a K salt, a Mg salt or a Zn salt.
6. The agent for skin external use as claimed in claim 1 , wherein water is further contained.
7. A cosmetic comprising the agent for skin external use of claim 1 .
8. A method for stabilizing an agent for skin external use containing a salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester, said higher fatty acid ester of ascorbic acid-2-phosphoric acid ester of the following formula (1):
wherein R is a group of an aliphatic carboxylic acid having 10 to 20 carbon atoms, comprising adding 1,2-pentanediol or 1,2-hexanediol or both to said salt.
9. An agent for skin external use, comprising:
a salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester, said higher fatty acid ester of ascorbic acid-2-phosphoric acid ester of the following formula (1):
wherein R is a residual group of an aliphatic carboxylic acid having 10 to 20 carbon atoms, and 1,2-hexanediol contained in an amount of not less than 0.05% by mass and less than 12% by mass.
10. The agent for skin external use as claimed in claim 9 , wherein R is a residual group of an aliphatic carboxylic acid selected from the group consisting of palmitic acid, 2-hexyldecanoic acid, stearic acid and isostearic acid.