Furan derivatives as EP
A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R 2 and R 5 is: (i) H or an optionally substituted C 1-4 alkyl group; or (ii) an optionally substituted C 5-7 aryl; and the other of R 2 and R 5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 R N is H or optionally substituted C 1-4 alkyl R 3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C 1-7 alkyl, C 5-20 aryl, or NR N3 R N4 , where R N3 and R N4 are independently selected from optionally substituted C 1-4 alkyl; or (iv) tetrazol-5-yl.
1. A compound of formula (I):
or a salt, hydrate or chemically protected form thereof, wherein:
either
R 2 is H or an optionally substituted C 1-4 alkyl group and R 5 is an optionally substituted C 5-7 aryl; or
R 5 is H or an optionally substituted C 1-4 alkyl group and R 2 is an optionally substituted C 5-7 aryl; m and n can be 0 or 1, and m+n=1 or 2
R N is H or optionally substituted C 1-4 alkyl
R 3 is either:
carboxy or tetrazole-5-yl
with the proviso that the compound in which R 3 is carboxy, n is 0, m is 1, R N is H, R 2 is methyl and R 5 is phenyl is excluded.
2. A compound according to claim 1 , wherein R 5 is an optionally substituted C 5-7 aryl group and R 2 is H or the optionally substituted C 1-4 alkyl group.
3. A compound according to claim 2 , wherein R 2 is selected from H or an optionally substituted C 1-3 alkyl group.
4. A compound according to claim 3 , wherein R 2 is a methyl group.
5. A compound according to claim 2 , wherein R 5 is a C 6 aryl group.
6. A compound according to claim 5 , wherein R 5 is phenyl.
7. A compound according to claim 1 wherein the C 5-7 aryl group of R 2 and R 5 is substituted by substituents selected from C 1-7 alkoxy groups.
8. A compound according to claim 1 , wherein n+m=1.
9. A compound according to claim 8 , wherein n is 0 and m is 1.
10. A compound according to claim 1 , wherein R N is H or methyl.
11. A method of treating a primary headache disorder comprising administering to a patient in need of treatment an effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.
12. A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable carrier or diluent.
13. The method according to claim 11 wherein the primary headache disorder is a migraine.