Novel pyridine Derivative and Pyrimidine Derivative (1)

1 . A compound represented by the following formula, a salt thereof or a hydrate of the foregoing:

wherein R 1 represents C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, C 1-6 alkoxy, 5- to 10-membered heteroaryl, a 3- to 10-membered non-aromatic heterocyclic group or a group represented by the formula —NR 11a R 11b , and R 1 may be substituted with a substituent selected from Substituent Group A or Substituent Group B, wherein R 11a and R 11b may be the same or different and each represents hydrogen, C 1-6 alkyl, C 3-6 alkenyl, C 3-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, C 1-6 alkoxy, 5- to 10-membered heteroaryl or a 4- to 10-membered non-aromatic heterocyclic group, and R 11a and R 11b may be substituted with a substituent selected from Substituent Group A or Substituent Group B;

R 2 and R 3 represent hydrogen;

R 4 , R 5 , R 6 and R 7 may be the same or different and each represents hydrogen, halogen, hydroxyl, cyano, trifluoromethyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, amino, mono-C 1-6 alkylamino, di-C 1-6 alkyl amino or a group represented by the formula —CO—R 12 , wherein R 12 represents hydrogen, hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, amino, mono-C 1-6 alkylamino or di-C 1-6 alkylamino;

R 8 represents hydrogen or C 1-6 alkyl;

R 9 represents C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, C 3-10 cycloalkyl-C 1-6 alkyl, C 6-10 aryl-C 1-6 alkyl, C 1-6 alkoxy, 5- to 10-membered heteroaryl, a 3- to 10-membered non-aromatic heterocyclic group, 5- to 10-membered heteroaryl-C 1-6 alkyl, 3- to 10-membered non-aromatic heterocyclic-C 1-6 alkyl or a group represented by the formula —NR 11a R 11b , and R 9 may be substituted with a substituent selected from Substituent Group A or Substituent Group B, wherein R 11a and R 11b represent the same meaning as recited above;

V 1 and V 2 may be the same or different and each represents oxygen or sulfur;

W represents a group represented by the formula —N(R W3 )—, wherein R W3 represents hydrogen or C 1-6 alkyl;

X represents a group represented by the formula —C(R 10 )═ or nitrogen, wherein R 10 represents hydrogen, halogen, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl or a group represented by the formula —CO—R 12 , wherein R 12 represents the same meaning as recited above; and

Y represents oxygen, sulfur, sulfinyl, sulfonyl or a group represented by the formula —N(R Y )—, wherein R Y represents hydrogen or C 1-6 alkyl,

wherein Substituent Group A consists of halogen, hydroxyl, mercapto, nitro, cyano and oxo;

wherein Substituent Group B consists of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, 5- to 10-membered heteroaryl, a 3- to 10-membered non-aromatic heterocyclic group, C 1-6 alkoxy, C 3-6 alkenyloxy, C 3-6 alkynyloxy, C 3-10 cycloalkoxy, C 6-10 aryloxy, 5- to 10-membered heteroaryloxy, 4- to 10-membered non-aromatic heterocyclicoxy, C 1-6 alkylthio, C 3-6 alkenylthio, C 3-6 alkynylthio, C 3-10 cycloalkylthio, C 6-10 arylthio, 5- to 10-membered heteroarylthio, 4- to 10-membered non-aromatic heterocyclicthio and a group represented by the formula -T 1 -T 2 -T 3 , and each group in Substituent Group B may be substituted with a substituent selected from Substituent Group C, wherein T 1 represents a direct bond or C 1-6 alkylene, T 2 represents carbonyl, sulfinyl, sulfonyl, a group represented by the formula —C(═O)—O—, a group represented by the formula —O—C(═O)—, a group represented by the formula —SO 2 —O—, a group represented by the formula —O—SO 2 —, a group represented by the formula —NR T1 —, a group represented by the formula —C(═O)—NR T1 , a group represented by the formula —NR T1 —C(═O)—, a group represented by the formula —SO 2 —NR T1 — or a group represented by the formula —NR T1 —SO 2 —, T 3 represents hydrogen, C 1-6 alkyl, C 3-6 alkenyl, C 3-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, 5- to 10-membered heteroaryl or a 4- to 10-membered non-aromatic heterocyclic group, and R T1 represents hydrogen or C 1-6 alkyl; and

wherein Substituent Group C consists of halogen, hydroxyl, mercapto, nitro, cyano, oxo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, 5- to 10-membered heteroaryl, a 3- to 10-membered non-aromatic heterocyclic group, C 1-6 alkoxy and C 1-6 alkylthio.

2 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein R 1 represents C 1-6 alkyl optionally substituted with a substituent selected from Substituent Group A or Substituent Group B recited in claim 1 .

3 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein R 1 represents C 1-6 alkyl optionally substituted with a substituent selected from Substituent Group D,

wherein Substituent Group D consists of amino, mono-C 1-6 alkylamino and di-C 1-6 alkylamino.

4 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein R 1 represents a 3- to 10-membered non-aromatic heterocyclic group optionally substituted with a substituent selected from Substituent Group A or Substituent Group B recited in claim 1 .

5 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein R 1 represent a group represented by the formula (II):

wherein a represents an integer of 1 to 4,

or a group represented by the formula (III):

wherein b represents an integer of 1 to 3, and Z represents oxygen, sulfur, carbonyl, sulfonyl or a group represented by the formula —NR Z —, wherein R Z represents hydrogen or C 1-6 alkyl, and the groups represented by the formula (II) or (III) may be substituted with a substituent selected from Substituent Group A or Substituent Group B recited in claim 1 .

6 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein R 1 represents azetidin-1-yl optionally substituted with a substituent selected from Substituent Group E, pyrrolidin-1-yl optionally substituted with a substituent selected from Substituent Group E, piperidin-1-yl optionally substituted with a substituent selected from Substituent Group E, azepan-1-yl optionally substituted with a substituent selected from Substituent Group E, piperazin-1-yl optionally substituted with a substituent selected from Substituent Group E, diazepan-1-yl optionally substituted with a substituent selected from Substituent Group E, morpholin-4-yl optionally substituted with a substituent selected from Substituent Group E, thiomorpholin-4-yl optionally substituted with a substituent selected from Substituent Group E or 1,1-dioxothiomorpholin-4-yl optionally substituted with a substituent selected from Substituent Group E,

wherein Substituent Group E consists of halogen, hydroxyl, mercapto, cyano, formyl, oxo, C 1-6 alkyl, C 3-10 cycloalkyl, C 1-6 alkoxy, amino, mono-C 1-6 alkylamino, di-C 1-6 alkylamino, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, diazepanyl and a group represented by -T 4 -T 5 , wherein T 4 represents carbonyl or sulfonyl, and T 5 represents C 1-6 alkyl, C 3-10 cycloalkyl, azetidinyl, pyrrolidinyl, piperidinyl, hydroxyl, C 1-6 alkoxy, amino, mono-C 1-6 alkylamino or di-C 1-6 alkylamino,

where each group included in Substituent Group E may be substituted with hydroxyl, C 1-6 alkyl, di-C 1-6 alkylamino, azetidinyl or pyrrolidinyl.

7 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein R 1 represents azetidin-1-yl optionally substituted with a substituent selected from Substituent Group E′, pyrrolidin-1-yl optionally substituted with a substituent selected from Substituent Group E′, piperidin-1-yl optionally substituted with a substituent selected from Substituent Group E′, piperazin-1-yl optionally substituted with a substituent selected from Substituent Group E′, diazepan-1-yl optionally substituted with a substituent selected from Substituent Group E′ or morpholin-4-yl optionally substituted with a substituent selected from Substituent Group E′,

wherein Substituent Group E′ consists of methyl, ethyl, dimethylamino, azetidinyl, pyrrolidinyl, piperidinyl and piperazinyl,

where each group included in Substituent Group E′ may be substituted with hydroxyl, methyl, dimethylamino, azetidinyl or pyrrolidinyl.

8 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein R 1 represents a group represented by the formula —NR 11a R 11b , wherein R 11a and R 11b represent the same meaning as recited in claim 1 .

9 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein R 1 represents a group represented by the formula —NR 11c R 11d , wherein R 11c represents hydrogen or C 1-6 alkyl, and R 11d represents C 1-6 alkyl or a group represented by the formula (IV):

wherein c represents an integer of 1 to 3, and Z 1 represents oxygen, sulfur, carbonyl, sulfonyl or a group represented by the formula —NR Z1 —, wherein R Z1 represents hydrogen or C 1-6 alkyl, and R 11d may be substituted with a substituent selected from Substituent Group A or Substituent Group B recited in claim 1 .

10 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein R 1 represents a group represented by the formula —NR 11e R 11f , wherein R 11e represents hydrogen or C 1-6 alkyl, and R 11f represents C 1-6 alkyl, pyrrolidin-3-yl, piperidin-3-yl, piperidin-4-yl or tetrahydropyran-4-yl, and R 11f may be substituted with a substituent selected from Substituent Group E recited in claim 6 .

11 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein R 1 represents a group represented by the formula —NR 11g R 11h , wherein R 11g represents hydrogen or methyl, and R 11h represents n-propyl, n-butyl, pyrrolidin-3-yl, piperidin-3-yl, piperidin-4-yl or tetrahydropyran-4-yl, and R 11h may be substituted with a substituent selected from Substituent Group E″,

wherein Substituent Group E″ consists of methyl, ethyl, n-propyl, acetyl, dimethylamino, diethylamino, azetidinyl, pyrrolidinyl and piperazinyl,

where each group included in Substituent Group E″ may be substituted with methyl or dim ethyl amino.

12 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein R 4 , R 5 , R 6 and R 7 may be the same or different and each represents hydrogen, halogen or C 1-6 alkyl.

13 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein R 8 represents hydrogen.

14 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein V 1 represents oxygen.

15 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein X represents a group represented by the formula —C(R 10a )═, wherein R 10a represents hydrogen, halogen or cyano.

16 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein X represents nitrogen.

17 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein Y represents oxygen.

18 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein V 2 represents sulfur.

19 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein W represents a group represented by the formula —NH— and V 2 represents sulfur.

20 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein V 2 represents oxygen.

21 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein W represents a group represented by the formula —NH— and V 2 represents oxygen.

22 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein R 9 represents C 1-6 alkyl optionally substituted with a substituent selected from Substituent Group A or Substituent Group B recited in claim 1 , C 3-10 cycloalkyl optionally substituted with a substituent selected from Substituent Group A or Substituent Group B recited in claim 1 , C 3-10 cycloalkyl-C 1-6 alkyl optionally substituted with a substituent selected from Substituent Group A or Substituent Group B recited in claim 1 , C 6-10 aryl-C 1-6 alkyl optionally substituted with a substituent selected from Substituent Group A or Substituent Group B recited in claim 1 , 5 - to 10-membered heteroaryl-C 1-6 alkyl optionally substituted with a substituent selected from Substituent Group A or Substituent Group B recited in claim 1 or 3- to 10-membered non-aromatic heterocyclic-C 1-6 alkyl optionally substituted with a substituent selected from Substituent Group A or Substituent Group B recited in claim 1 .

23 . A compound according to claim 1 , a salt thereof or a hydrate of the foregoing, wherein R 9 represents C 3-10 cycloalkyl-C 1-6 alkyl optionally substituted with a substituent selected from Substituent Group A or Substituent Group B recited in claim 1 or C 6-10 aryl-C 1-6 alkyl optionally substituted with a substituent selected from Substituent Group A or Substituent Group B recited in claim 1 .

24 . A pharmaceutical composition comprising a compound according to claim 1 , a salt thereof or a hydrate of the foregoing.

25 . An inhibitor for hepatocyte growth factor receptor, comprising a compound according to claim 1 , a salt thereof or a hydrate of the foregoing.

26 . An angiogenesis inhibitor comprising a compound according to claim 1 , a salt thereof or a hydrate of the foregoing.

27 . An anti-tumor agent comprising a compound according to claim 1 , a salt thereof or a hydrate of the foregoing.

28 . An anti-tumor agent according to claim 27 , wherein tumor is a pancreatic cancer, a gastric cancer, a colorectal cancer, a breast cancer, a prostate cancer, a lung cancer, a renal cancer, a brain tumor or an ovarian cancer.

29 . An inhibitor for cancer metastasis, comprising a compound according to claim 1 , a salt thereof or a hydrate of the foregoing.