Pharmaceutical Preparation Containing Gabapentin
A gabapentin granulate obtained by granulating gabapentin with PEG having a melting point comprised between 50 and 80° C. and pharmaceutical compositions containing it, are described.
1 . A gabapentin granulate obtained by granulating gabapentin with PEG having a melting point comprised between 50 and 80° C.
2 . The granulate according to claim 1 , wherein the gabapentin is present in an amount higher than 80% by weight.
3 . A granulate according to claim 1 , wherein the gabapentin is present in quantities higher than 90% by weight.
4 . A granulate according to claim 1 , wherein the gabapentin is present in quantities equal to 98% by weight, the PEG being 2%.
5 . A gabapentin pharracutical composition under tablet form obtained by compressing a granulate according to claim 1 .
6 . A gabapentin pharmaceutical composition under capsule form obtained by filling-in a gelatine capsule with a granulate according to claim 1 .
7 . A gabapentin pharmaceutical composition under the tablet form obtained by compressing a granulate according to claim 1 and known additives useful for the preparation of tablets.
8 . A gabapentin pharmaceutical composition under tablet form according to claim 7 , wherein the additives are chosen among diluents, lubricants, disgregants and glydants.
9 . A gabapentin pharmaceutical composition under tablet form according to claim 7 , wherein the additives represent between 0 and 30% by weight and preferably between 0 and 20% by weight of the tablet, the remaining to 100% being a granulate of claim 1 .
10 . A gabapcntin pharmaceutical composition under capsule form obtained by filling-in a gelatine capsule with a granulate according to claim 1 and known additives useful for the preparation of pharmaceutical forms in capsule.
11 . A gabapentin pharmaceutical composition under the capsule form according to claim 10 , wherein the additives represent between 0 and 30% by weight and preferably between 0 and 20% by weight of the capsule content, the remaining to 100% being a granulate of claim 1 .
12 . A gabapentin granulate obtained by granulating gabapentin with PEG having a melting point comprised between 50 and 80° C. and additives known for the preparation of solid pharmaceutical forms chosen among tablets and capsules.
13 . A gabapentin granulate obtained by granulating gabapentin according to claim 12 , wherein the additives are chosen among diluents, lubricants, disgregants and glydants.
14 . A granulate according to claim 12 having the following composition:
gabapentin
80-98% by weight
PEG
2-25% by weight
additives
0-20% by weight
15 . A gabapentin pharmaceutical composition under tablet form obtained by compressing a granulate according to claim 12 .
16 . A gabapentin pharmaceutical composition under capsule form obtained by filling-in a gelatine capsule with a granulate according to claim 12 .
17 . A gabapentin chemical composition under tablet or capsule form containing a granulate according to claim 1 .
18 . A gabapentin chemical composition under tablet or capsule form containing a granulate according to claim 12 .