Oligosaccharide compositions and use thereof in the treatment of infection
Oligosaccharides and oligosaccharides linked to backbones such as proteins, methods for making such oligosaccharides and methods for using them to treat and/or prevent various disorders are described.
1. A method for treating or reducing the risk of infection, the method comprising administering to a subject in need thereof a composition containing (a) a molecule including a fucose group in an α1,3 linkage or an α1,4 linkage to a galactose group, (b) 2′-fucosyllactose (2′FL) or 2′-fucosyl-N-acetyllactosamine (2′FLNAc), and (c) a pharmaceutically acceptable carrier; wherein said composition is not a mammalian milk.
2. The method of claim 1 , wherein the molecule includes a fucose group in an α1,3 linkage to a galactose group.
3. The method of claim 2 , wherein the composition contains 2′FL.
4. The method of claim 2 , wherein the composition contains 2′FLNAc.
5. The method of claim 1 , wherein the molecule includes a fucose group in an α1,4 linkage to a galactose group.
6. The method of claim 5 , wherein the composition contains 2′FL.
7. The method of claim 5 , wherein the composition contains 2′FLNAc.
8. The method of claim 1 , wherein the composition contains both 2′FL and 2′FLNAc.
9. The method of claim 8 , wherein the molecule includes a fucose group in an α1,3 linkage to a galactose group.
10. The method of claim 8 , wherein the molecule includes a fucose group in an α1,4 linkage to a galactose group.
11. The method of claim 1 , wherein the composition contains 2′FL covalently attached to a protein or 2′FLNAc covalently attached to a protein.
12. The method of claim 11 , wherein the molecule includes a fucose group in an α1,3 linkage to a galactose group.
13. The method of claim 12 , wherein the composition contains 2′FL covalently attached to a protein.
14. The method of claim 12 , wherein the composition contains 2′FLNAc covalently attached to a protein.
15. The method of claim 11 , wherein the molecule includes a fucose group in an α1,4 linkage to a galactose group.
16. The method of claim 15 , wherein the composition contains 2′FL covalently attached to a protein.
17. The method of claim 15 , wherein the composition contains 2′FLNAc covalently attached to a protein.
18. The method of claim 11 , wherein the composition contains 2′FL and 2′FLNAc that are both covalently attached to a protein.
19. The method of claim 18 , wherein the molecule includes a fucose group in an α1,3 linkage to a galactose group.
20. The method of claim 18 , wherein the molecule includes a fucose group in an α1,4 linkage to a galactose group.