Benzo-1,4-diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors, preparation and therapeutic use thereof

1. A compound represented by formula (I):

wherein:

R 1 represents a member selected from the group consisting of hydrogen, (C 1 -C 6 ) alkyl, aryl, (C 1 -C 6 )alkylaryl, aryl(C 1 -C 6 )alkyl group, (C 3 -C 6 ) alkenyl, and (C 3 -C 6 ) alkenylaryl,

R 7 represents a substituted or unsubstituted aryl or heteroaryl group, wherein said heteroaryl group contains from 4 to 18 carbon atoms and one or more heteroatoms selected from N, O and S, wherein R 7 is a substituted aryl group, it is mono- or bis-substituted by the following groups: (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyloxy, (C 1 -C 6 )alkyloxy, (C 3 -C 6 )alkenyloxy, aryloxy, acyl, halogen, trifluoromethyl, difluoromethyl, cyano, nitro, hydroxy, carboxamide, amino, (C 1 -C 6 )aminoalkyl, (C 1 -C 6 )aminodialkyl, NCOR 12 where R 12 is selected from the group consisting of (C 1 -C 6 )alkyl, (C 1 -C 6 )alkylaryl, aryl, and —CONR 13 R 14 wherein R 13 and R 14 , independently from each other, are selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )alkenyl, alkylaryl, alkenylaryl, and aryl, and wherein R 7 is a substituted heteroaryl group, it is substituted with one or two substituents independently selected from the group consisting of halogen, amino, aminoacyl, CONH 2 , (C 1 -C 6 )alkyl, aryloxy and (C 1 -C 6 )alkyloxy,

R 8 represents hydrogen or an OR 10 group, wherein R 10 is a selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )alkenyl, trifluoromethyl, difluoromethyl, (C 3 -C 6 )alkenylaryl, aryl, and a heterocyclic group, aromatic or not, having from 4 to 18 carbon atoms and 1 to 3 heteroatoms chosen from O, N and S,

when R 10 represents an aryl, it is mono- or bis-substituted by substituents selected from: hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyloxy, (C 1 -C 6 )alkyloxy, (C 3 -C 6 )alkenyloxy, halogen, trifluoromethyl, difluoromethyl, cyano, nitro, hydroxy, carboxamide, amino, (C 1 -C 6 )aminoalkyl, (C 1 -C 6 )aminodialkyl NCOR 12 wherein R 12 is selected from the group consisting of (C 1 -C 6 )alkyl, (C 1 -C 6 )alkylaryl and aryl, and —CONR 13 R 14 wherein R 13 and R 14 , independently from each other, are selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )alkenyl, alkylaryl, alkenylaryl, and aryl,

R X represents a member selected from the group consisting of hydrogen, halogen, methyl, methoxy, acetyl, trifluoromethyl, CN, COH and CONH 2 ,

R Y represents a member selected from the group consisting of hydrogen, halogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, arylalkyl, (C 3 -C 6 )cycloalkyloxy, COH, (C 1 -C 6 )alkyloxy, alkenyl, (C 3 -C 8 )alkenyloxy, alkynyl, alkynyloxy, acyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, cyano, nitro, hydroxy, carboxamide, amino, (C 1 -C 6 )aminoalkyl, (C 1 -C 6 )aminodialkyl, NHCOR 12 where R 12 is as defined above, and —CONR 13 R 14 wherein R 13 and R 14 are as defined above,

with the proviso that, when R 8 is hydrogen, then one or R X and R Y is other than hydrogen,

or a pharmaceutically acceptable salt thereof.

2. The compound of formula (I) according to claim 1 , wherein R 8 is hydrogen, alkoxy, or aryloxy.

3. The compound of formula (I) according to claim 1 , wherein at least one of R X and R Y is other than hydrogen.

4. The compound of formula (I) according to claim 1 , wherein R Y is an hydrogen atom and R X is other than hydrogen.

5. The compound of formula (I) according to claim 1 , wherein the one of R X and R Y , that is other than hydrogen, is on position 3 of the phenyl group represented in formula (I).

6. The compound of formula (I) according to claim 4 , wherein R X , is on position 3 of the phenyl group represented in formula (I).

7. The compound of formula (I) according to claim 1 , wherein R X represents CONH 2 , CN, or COCH 3 , and is on position 3 or 4 of the phenyl group represented in formula (I).

8. The compound of formula (I) according to claim 1 , wherein R Y is selected from the group consisting of hydrogen, halogen, CF 3 , (C 1 -C 6 )aminoalkyl, (C 1 -C 6 )aminodialkyl, —NHCOR 12 , —CONH 2 , (C 1 -C 3 alkyloxy and (C 1 -C 6 )alkyl.

9. The compound of formula (I) according to claim 1 , wherein R 1 represents hydrogen, alkyl, alkenyl, or arylalkyl.

10. The compound of formula (I) according to claim 1 , wherein R 7 represents a furanyl group.

11. The compound of formula (I) according to claim 1 , wherein R 7 represents an unsubstituted aryl group.

12. The compound of formula (I) according to claim 1 , wherein R 7 represents a substituted aryl or heteroaryl group.

13. The compound of formula (I) according to claim 1 , wherein R 7 represents an aryl or heteroaryl group substituted with one or two, substituents independently selected from the group consisting of halogen, amino, aminoacyl, CONH 2 , (C 1 -C 6 )alkyl, aryloxy and (C 1 -C 6 )alkyloxy.

14. The compound of formula (I) according to claim 1 , wherein R 7 is an aryl or heteroaryl group substituted with an alkoxy group.

15. The compound of formula (I) according to claim 1 , wherein R 7 is a phenyl group substituted by at least one group on the ortho position.

16. The compound of formula (I) according to claim 1 , wherein R 7 is a substituted phenyl group selected from the group consisting of 4-methoxy-phenyl, 4-fluoro-phenyl, 2-methoxy-phenyl, 2-chloro-phenyl, 4-chloro-phenyl, 3-chloro-phenyl, 3-methoxy-phenyl, 2,5-dimethoxy-phenyl, 2,6-dimethoxy-phenyl, 4-carbamoyl-phenyl, 4-cyanophenyl, 2,4-dimethoxy-phenyl, 4-carboxamide-phenyl, 4-acetyl-phenyl, 2-isopropoxy-phenyl, 2-phenoxy-phenyl, and 3,4-dimethoxy-phenyl groups.

17. A compound of formula (I) in accordance with claim 1 , wherein said compound is selected from the group consisting of:

3-(8-Methoxy-1-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile;

3-[7-(4-Fluoro-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[8-Methoxy-7-(2-methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[8-Methoxy-7-(4-methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[7-(2-Chloro-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-1-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[7-(3-Chloro-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[7-(4-Chloro-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-(7-Furan-2-yl-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile;

3-(1-Methyl-2-oxo-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile

3-[8-Methoxy-7-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-(1-Methyl-2-oxo-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile;

3-[7-(2-Methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[7-(3-Methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[7-(4-Methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[7-(2,5-Dimethoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[7-(2,6-Dimethoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[7-(2,4-Dimethoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

8-Ethoxy-1-ethyl-5,7-diphenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

3-(8-Methoxy-1-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide;

3-[7-(4-fluoro-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[8-Methoxy-7-(2-methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[8-Methoxy-7-(4-methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(2-Chloro-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(3-Chloro-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(4-Chloro-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-(7-Furan-2-yl-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide;

3-(1-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide;

3-[7-(2-methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(3-methoxy-phenyl)-1-methyl-2-oxa-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(4-methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(2,5-Dimethoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(2,6-Dimethoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(2,4-Dimethoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-(8-Methoxy-7-(4-benzamide)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide;

3-[1-Hexyl-8-methoxy-7-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[8-Methoxy-7-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[8-Methoxy-7-6-methoxy-phenyl)-2-oxo-1-propyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[8-Methoxy-7-(2-methoxy-phenyl)-2-oxo-1-phenethyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[1-Benzyl-8-methoxy-7-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

5-(3-Chloro-phenyl)-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(2-Chloro-phenyl)-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(4-Chloro-phenyl)-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

3-(8-Methoxy-1-methyl-2-oxo-7-(4-cyanophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile;

3-[1-Benzyl-8-methoxy-7-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[8-Methoxy-7-(2-methoxy-phenyl)-2-oxo-1-propyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[8-Methoxy-7-(2-methoxy-phenyl)-2-oxo-1-phenethyl-2,3-dihydro-1H-benzo[e][4]diazepin-5-yl]-benzamide;

3-[1-Hexyl-8-methoxy-7-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(4-Acetyl-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[7-(4-Acetyl-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

5-(4-Methoxy-phenyl)-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(2-Methoxy-phenyl)-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

3-(7-Furan-2-yl-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile;

3-[7-(3,4-Dimethoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[7-(3,4-Dimethoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

5-(3,5-Dichloro-phenyl)-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(3,4-Dichloro-phenyl)-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(4-Fluoro-phenyl)-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(3-Acetyl-phenyl)-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

1-Methyl-7-phenyl-5-(3-trifluoromethyl-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

1-Methyl-5-(4-methyl-3-nitro-phenyl)-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

1-Methyl-7-phenyl-5-(4-trifluoromethoxy-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(3-Bromo-phenyl)-8-methoxy-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

3-[7-(2-Isopropoxy-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

5-(3,4-Dimethoxy-phenyl)-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

1-Methyl-5-(3-nitro-phenyl)-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(3-Hex-1-ynyl-phenyl)-8-methoxy-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

{3-[3-(8-Methoxy-1-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-phenyl]-prop-2-ynyl}-carbamic acid tert-butyl ester;

5-(3-Amino-phenyl)-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

3-(1-Methyl-2-oxo-8-phenoxy-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile;

3-[7-(2-Methoxy-phenyl)-1-methyl-2-oxo-8-phenoxy-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[7-(2-Chloro-phenyl)-1-methyl-2-oxo-8-phenoxy-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-(1-Methyl-2-oxo-8-phenoxy-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide;

3-[7-(2-Chloro-phenyl)-1-methyl-2-oxo-8-phenoxy-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(2-Methoxy-phenyl)-1-methyl-2-oxo-8-phenoxy-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

7-(2,6-Dimethoxy-phenyl)-5-(4-methoxy-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

8-Methoxy-5-(4-methoxy-phenyl)-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-5-one;

7-(2,6-Dimethoxy-phenyl)-1-methyl-5-(4-methyl-3-nitro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

3-[7-(2-Isopropoxy-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

5-(3-Methoxy-phenyl)-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(3-Bromo-phenyl)-8-methoxy-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

3-[7-(2-Chloro-6-methoxy-phenyl)-2-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[7-(5-Chloro-2-methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[7-(2-Chloro-6-methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(5-Chloro-2-methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-(2-Oxo-7-phenyl-8-trifluoromethoxy-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile;

3-(1-Methyl-2-oxo-7-phenyl-8-trifluoromethoxy-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile;

3-(1-Methyl-2-oxo-7-phenyl-8-trifluoromethoxy-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide;

3-[1-Methyl-2-oxo-7-(2-phenoxy-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[7-(2,6-Dimethoxy-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[8-Methoxy-1-methyl-2-oxo-7-(2-phenoxy-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile;

3-[1-Methyl-2-oxo-7-(2-phenoxy-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(2,6-Dimethoxy-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[8-Methoxy-1-methyl-2-oxo-7-(2-phenoxy-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

8-Methoxy-1-methyl-7-phenyl-5-[3-(4-phenyl-butyl-phenyl]-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

8-Methoxy-5-[3-(3-methoxy-prop-1-ynyl)-phenyl]-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

{3-[4-(8-Methoxy-1-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-phenyl]-prop-2-ynyl}carbamic acid tert-butyl ester;

8-Methoxy-1-methyl-7-phenyl-5-(4-phenylethynyl-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

8-Methoxy-5-[4-(3-methoxy-prop-1-ynyl)-phenyl]-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(3,4-Dichloro-phenyl)-7-(2,6-dimethoxy-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

7-(2,6-Dimethoxy-phenyl)-5-(4-fluoro-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(3,4-Dimethoxy-phenyl)-7-(2,6-dimethoxy-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(2-Bromo-phenyl)-8-methoxy-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

8-Methoxy-5-[3-(3-methoxy-propyl)-phenyl]-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(2-Bromo-phenyl)-8-methoxy-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(4-Hex-1-ynyl-phenyl)-8-methoxy-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

8-Methoxy-5-[4-(3-methoxy-propyl)-phenyl]-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

{3-[4-(8-Methoxy-1-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-phenyl]-propyl}carbamic acid tert-butyl ester;

8-Methoxy-5-(4-methoxy-phenyl)-7-(2-methoxy-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

7-(2,6-Dimethoxy-phenyl)-8-methoxy-5-(4-methoxy-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

7-(2,5-Dimethoxy-phenyl)-8-methoxy-5-(4-methoxy-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

7-(2-Fluoro-6-methoxy-phenyl)-8-methoxy-5-(4-methoxy-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

8-Methoxy-5-(4-methoxy-phenyl)-1-methyl-7-(2-phenoxy-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(4-Bromo-phenyl)-8-methoxy-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

5-(4-Bromo-phenyl)-8-methoxy-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; and

7-(2,6-Dimethoxy-phenyl)-1-methyl-5-m-tolyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one.

18. A compound of formula (I) in accordance with claim 1 , wherein said compound is selected from the group consisting of:

3-[7-(2,6-dimethoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(2,5-dimethoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[8-methoxy-7-(4-methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[8-methoxy-7-(2-methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(2-chloro-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-(8-methoxy-1-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide;

7-(2,6-Dimethoxy-phenyl)-5-(4-methoxy-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

3-[7-(2-Chloro-6-methoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(2,6-Dimethoxy-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[8-Methoxy-1-methyl-2-oxo-7-(2-phenoxy-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

5-(2,4-Dichloro-phenyl)-7-(2,6-dimethoxy-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

7-(2,6-Dimethoxy-phenyl)-1-methyl-5-m-tolyl-1,3-dihydro-benzo[e][1,4]diazepin-5-one; and

7-(2,6-Dimethoxy-phenyl)-8-methoxy-5-(4-methoxy-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one.

19. A compound of formula (I) in accordance with claim 1 , wherein said compound is selected from the group consisting of:

3-[7-(2,5-Dimethoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(2,6-Dimethoxy-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

3-[7-(2,6-Dimethoxy-phenyl)-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzamide;

7-(2,6-Dimethoxy-phenyl)-5-(4-methoxy-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;

7-(2,6-Dimethoxy-phenyl)-5-(4-fluoro-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; and

7-(2,6-Dimethoxy-phenyl)-8-methoxy-5-(4-methoxy-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one.

20. A pharmaceutical composition comprising at least one compound of formula (I) in accordance with claim 1 , and a pharmaceutically acceptable vehicle or support.