Methods for inhibiting tumor cell growth
The invention methods using a insulin-like growth factor receptor inhibitor to inhibit tumor cell growth in a subject in need thereof.
1. A method of inhibiting multiple myeloma cell growth in a subject comprising administering to said subject a cytotoxic or a chemotherapeutic agent and a composition comprising an insulin-like growth factor receptor-1 (IGF-1R) inhibitor, wherein said IGF-1R inhibitor is ADW-742 or NVP-AEW541.
2. The method of claim 1 , wherein said composition is administered concomitantly with said agent.
3. The method of claim 1 , wherein said composition is administered within 48 hours after said agent.
4. The method of claim 1 , wherein said composition is administered within 24 hours after said agent.
5. The method of claim 1 , wherein said composition is administered within 12 hours after said agent.
6. The method of claim 1 , wherein said composition is administered within 3-12 hours after said agent.
7. The method of claim 1 , wherein said composition is administered over a preselected period of time.
8. The method of claim 7 , wherein said preselected period of time is about 1 to 2 days.
9. The method of claim 1 , wherein the dose of said agent is sub-therapeutic.
10. The method of claim 1 , wherein the dose of said IGF-1R inhibitor is sub-therapeutic.
11. The method of claim 1 , wherein the dose of said IGF- 1 R inhibitor is in an amount sufficient to cause hyperglycemia, ketosis or glucosurioa.
12. The method of claim 1 , wherein said chemotherapeutic agent is doxorubicin, melphalan or dexamethasone.
13. The method of claim 1 , wherein said IGF-1R inhibitor is ADW-742.
14. The method of claim 1 , wherein said IGF-1R inhibitor is NVP-AEW541.