Control Of Feeding Behavior By Changing Neuronal Energy Balance
Obesity is a worldwide health issue, affecting children and adults in developed and developing countries. Obesity is a disorder of both energy metabolism and appetite regulation, and may be understood as a dysfunction of energy balance. Applicants have found a means for regulating food intake by a subject by administering a compound to the subject which affects neuronal energy balance. Applicants have found a means for regulating food intake by a subject administering a compound to the subject which targets the activity of AMPK, in particular inhibiting activation, in particular hypothalamic. Applicants have also found a method of inducing weight loss in a subject by decreasing the subjects appetite by administering a compound to the subject which increases the subject's neuronal energy balance.
1 . A method for regulating food intake by administering a compound to a subject, wherein the compound affects the activity of AMPK.
2 . The method of claim 1 , wherein the AMPK is hypothalmic AMPK.
3 . The method of claim 1 , wherein the compound is not C75.
4 . The method of claim 1 , wherein the compound is C75.
5 . The method of claim 1 , wherein the compound inhibits AMPK
6 . The method of claim 1 , wherein the compound stimulates AMPK.
7 . The method of claim 1 , wherein the subject is a human.
8 . The method of claim 1 , wherein the subject is a mammal but is not a human.
9 . A method of altering food intake in a subject by administering a compound to the subject which changes the subject's neuronal energy balance.
10 . The method of claim 9 , wherein the compound decreases the subject's neuronal energy balance.
11 . The method of claim 9 , wherein the compound increases the subject's neuronal energy balance.
12 . The method of claim 9 , wherein the subject is a human.
13 . The method of claim 9 , wherein the subject is a mammal but is not a human.
14 . The method of claim 9 , wherein the compound is not C75.