Aniline derivatives as selective androgen receptor modulators

1. A compound of formula (I)

or a salt thereof, wherein

R 1 is -(Q 1 ) x -R 5 ;

Q 1 is C 1 -C 6 alkylene;

x is 0 or 1;

R 5 is —CF 3 or cyclopropyl;

R 2 is -(Q 3 )-(Q 4 )-R 6 , or -(Q 3 )-CN;

Q 3 is C 1 -C 6 alkylene;

Q 4 is —C(O)—, —C(S)—, or —C(NR 7 )—,

R 7 is H or alkyl;

R 6 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, hydroxy, C 1 -C 6 alkoxy, phenoxy, benzyloxy, or —N(R 8 )(R 9 )

R 8 and R 9 each independently are H, hydroxy, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, -(Q 5 ) y -C 3 -C 6 cycloalkyl, —N(R 10 )(R 11 );

Q 5 is C 1 -C 6 alkylene;

y is 0 or 1;

R 10 and R 11 each independently are H or C 1 -C 6 alkyl;

R 3 is —CN, —NO 2 , or halogen; and

R 4 is —CN, —NO 2 , halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, hydroxyl, C 1 -C 6 alkoxy, phenyl, naphthyl, phenoxy or benzyloxy.

2. The compound of claim 1 wherein R 3 is —CN.

3. The compound of claim 1 wherein R 4 is halogen, C 1 -C 5 haloalkyl, —CN or C 1 -C 6 alkyl.

4. The compound of claim 1 wherein Q 1 is methylene.

5. The compound of claim 1 wherein Q 3 is methylene.

6. A compound selected from:

1,1-dimethylethyl N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(cyclopropylmethyl)glycinate;

N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(cyclopropylmethyl)glycine;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 2 -(cyclopropylmethyl)-N 1 -methylglycinamide;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 2 -(cyclopropylmethyl)glycinamide;

1,1-dimethylethyl N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(2,2,2-trifluoroethyl)glycinate;

N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(2,2,2-trifluoroethyl)glycine;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 2 -(2,2,2-trifluoroethyl)glycinamide;

methyl N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(2,2,2-trifluoroethyl)glycinate;

1-methylethyl N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(2,2,2-trifluoroethyl)glycinate;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 1 -methyl-N 2 -(2,2,2-trifluoroethyl)glycinamide;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 1 -ethyl-N 2 -(2,2,2-trifluoroethyl)glycinamide;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 1 -cyclohexyl-N 2 -(2,2,2-trifluoroethyl)glycinamide;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 1 ,N 1 -dimethyl-N 2 -(2,2,2-trifluoroethyl)glycinamide;

2-[4-cyano(2,2,2-trifluoroethyl)-3-(trifluoromethyl)anilino]-N-methylacetohydrazide;

2-[4-cyano(2,2,2-trifluoroethyl)-3-(trifluoromethyl)anilino]-N′,N′-dimethylacetohydrazide;

methyl N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(2,2,2-trifluoroethyl)alaninate;

N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(2,2,2-trifluoroethyl)alanine;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 2 -(2,2,2-trifluoroethyl)alaninamide;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 2 -methyl-N 1 -(2,2,2-trifluoroethyl)alaninamide;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 1 -ethyl-N 2 -(2,2,2-trifluoroethyl)alaninamide;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 1 ,N 1 -dimethyl-N 2 -(2,2,2-trifluoroethyl)alaninamide;

1,1-dimethylethyl 2-[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]butanoate;

2-[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]butanoic acid;

2-[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]butanamide;

2-[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]-N-methylbutanamide;

2-[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]-N-ethylbutanamide;

2-[[4-cyano-3-(trifluoromethylphenyl](2,2,2-trifluoroethyl)amino]-N,N-dimethylbutanamide;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 2 -(cyclopropylmethyl)-N 1 -ethylglycinamide;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 1 ,N 2 -bis(cyclopropylmethyl)glycinamide;

1,1-dimethylethyl N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(cyclopropylmethyl)alaninate;

N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(cyclopropylmethyl)alanine;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 2 -(cyclopropylmethyl)alaninamide;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 2 -(cyclopropylmethyl)-N 1 -methylalaninamide;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 2 -(cyclopropylmethyl)-N 1 -ethylalaninamide;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 2 -(cyclopropylmethyl)-N 1 ,N 1 -dimethylalaninamide;

4-[(cyanomethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile;

4-[(1-cyanoethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile;

methyl 3-[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]-2-methylpropanoate;

4-[(2-cyanopropyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 2 -(2,2,2-trifluoro-1-methylethyl)glycinamide;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 2 -[1-(trifluoromethyl)propyl]glycinamide,

1,1-dimethylethyl N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(3,3,3-trifluoropropyl)glycinate;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 2 -(3,3,3-trifluoropropyl)glycinamide;

4-[(cyanomethyl)(3,3,3-trifluoropropyl)amino]-2-(trifluoromethyl)benzonitrile;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 2 -(3,3,3-trifluoropropyl)alaninamide;

N 2 -[4-cyano-3-(trifluoromethyl)phenyl]-N 1 -methyl-N 2 -(3,3,3-trifluoropropyl)alaninamide;

1,1-dimethylethyl N-(3-chloro-4-cyanophenyl)-N-(2,2,2-trifluoroethyl)glycinate;

N-(3-chloro-4-cyanophenyl)-N-(2,2,2-trifluoroethyl)glycine;

N 2 -(3-chloro-4-cyanophenyl)-N 2 -(2,2,2-trifluoroethyl)glycinamide;

N 2 -(3-chloro-4-cyanophenyl)-N 1 -methyl-N 2 -(2,2,2-trifluoroethyl)glycinamide;

N 2 -(3-chloro-4-cyanophenyl)-N 1 -ethyl-N 2 -(2,2,2-trifluoroethyl)glycinamide;

1,1-dimethylethyl N-(3-chloro-4-cyanophenyl)-N-(2,2,2-trifluoroethyl)alaninate;

N-(3-chloro-4-cyanophenyl)-N-(2,2,2-trifluoroethyl)alanine;

N 2 -(3-chloro-4-cyanophenyl)-N 2 -(2,2,2-trifluoroethyl)alaninamide;

N 2 -(3-chloro-4-cyanophenyl)-N 1 -methyl-N 2 -(2,2,2-trifluoroethyl)alaninamide;

N 2 -(3-chloro-4-cyanophenyl)-N 1 -ethyl-N 2 -(2,2,2-trifluoroethyl)alaninamide;

1,1-dimethylethyl 2-[(3-chloro-4-cyanophenyl)(2,2,2-trifluoroethyl)amino]butanoate;

2-[(3-chloro-4-cyanophenyl)(2,2,2-trifluoroethyl)amino]butanamide;

2-[(3-chloro-4-cyanophenyl)(2,2,2-trifluoroethyl)amino]-N-methylbutanamide;

2-[(3-chloro-4-cyanophenyl)(2,2,2-trifluoroethyl)amino]-N-ethylbutanamide;

1,1-dimethylethyl N-(3-chloro-4-cyanophenyl)-N-(cyclopropylmethyl)glycinate;

N-(3-chloro-4-cyanophenyl)-N-(cyclopropylmethyl)glycine;

N 2 -(3-chloro-4-cyanophenyl)-N 2 -(cyclopropylmethyl)glycinamide;

N 2 -(3-chloro-4-cyanophenyl)-N 2 -(cyclopropylmethyl)-N 1 -methylglycinamide;

N 2 -(3-chloro-4-cyanophenyl)-N 2 -(cyclopropylmethyl)-N 1 -ethylglycinamide;

2-chloro-4-[(cyanomethyl)(cyclopropylmethyl)amino]benzonitrile;

1,1-dimethylethyl N-(3-chloro-4-cyanophenyl)-N-(cyclopropylmethyl)alaninate;

N-(3-chloro-4-cyanophenyl)-N-(cyclopropylmethyl)alanine;

N 2 -(3-chloro-4-cyanophenyl)-N 2 -(cyclopropylmethyl)alaninamide;

N 2 -(3-chloro-4-cyanophenyl)-N 2 -(cyclopropylmethyl)-N 1 -methylalaninamide;

N 2 -(3-chloro-4-cyanophenyl)-N 2 -(cyclopropylmethyl)-N 1 -ethylalaninamide;

1,1-dimethylethyl 2-[(3-chloro-4-cyanophenyl)(cyclopropylmethyl)amino]butanoate;

2-[(3-chloro-4-cyanophenyl)(cyclopropylmethyl)amino]butanoic acid;

2-[(3-chloro-4-cyanophenyl)(cyclopropylmethyl)amino]butanamide;

2-[(3-chloro-4-cyanophenyl)(cyclopropylmethyl)amino]-N-methylbutanamide;

2-[(3-chloro-4-cyanophenyl)(cyclopropylmethyl)amino]-N-ethylbutanamide;

methyl N-(3,4-dicyanophenyl)-N-(2,2,2-trifluoroethyl)glycinate;

1,1-dimethylethyl N-(3,4-dicyanophenyl)-N-(2,2,2-trifluoroethyl)glycinate;

N 2 -(3,4-dicyanophenyl)-N 2 -(2,2,2-trifluoroethyl)glycinamide;

N 2 -(3,4-dicyanophenyl)-N 1 -methyl-N 2 -(2,2,2-trifluoroethyl)glycinamide;

N 2 -(3,4-dicyanophenyl)-N 1 -ethyl-N 2 -(2,2,2-trifluoroethyl)glycinamide;

1,1-dimethylethyl N-(3,4-dicyanophenyl)-N-(2,2,2-trifluoroethyl)alaninate;

N-(3,4-dicyanophenyl)-N-(2,2,2-trifluoroethyl)alanine;

N 2 -(3,4-dicyanophenyl)-N 2 -(2,2,2-trifluoroethyl)alaninamide;

N 2 -(3,4-dicyanophenyl)-N 1 -methyl-N 2 -(2,2,2-trifluoroethyl)alaninamide;

N 2 -(3,4-dicyanophenyl)-N 1 -ethyl-N 2 -(2,2,2-trifluoroethyl)alaninamide;

1,1-dimethylethyl 2-[(3,4-dicyanophenyl)(2,2,2-trifluoroethyl)amino]butanoate;

2-[(3,4-dicyanophenyl)(2,2,2-trifluoroethyl)amino]butanoic acid;

2-[(3,4-dicyanophenyl)(2,2,2-trifluoroethyl)amino]butanamide;

2-[(3,4-dicyanophenyl)(2,2,2-trifluoroethylamino]-N-methylbutanamide;

2-[(3,4-dicyanophenyl)(2,2,2-trifluoroethyl)amino]-N-ethylbutanamide;

1,1-dimethylethyl N-(cyclopropylmethyl)-N-(3,4-dicyanophenyl)glycinate;

N-(cyclopropylmethyl)-N-(3,4-dicyanophenyl)glycine;

N 2 -(cyclopropylmethyl)-N 2 -(3,4-dicyanophenyl)glycinamide;

N 2 -(cyclopropylmethyl)-N 2 -(3,4-dicyanophenyl)-N 1 -methylglycinamide;

N 2 -(cyclopropylmethyl)-N 2 -(3,4-dicyanophenyl)-N 1 -ethylglycinamide;

4-[(cyanomethyl)(cyclopropylmethyl)amino]-1,2-benzenedicarbonitrile;

1,1-dimethylethyl N-(cyclopropylmethyl)-N-(3,4-dicyanophenyl)alaninate;

N-(cyclopropylmethyl)-N-(3,4-dicyanophenyl)alanine;

N 2 -(cyclopropylmethyl)-N 2 -(3,4-dicyanophenyl)-N 1 -methylalaninamide;

N 2 -(cyclopropylmethyl)-N 2 -(3,4-dicyanophenyl)-N 1 -ethylalaninamide;

1,1-dimethylethyl 2-[(cyclopropylmethyl)(3,4-dicyanophenyl)amino]butanoate;

2-[(cyclopropylmethyl)(3,4-dicyanophenyl)amino]butanoic acid;

2-[(cyclopropylmethyl)(3,4-dicyanophenyl)amino]butanamide;

2-[(cyclopropylmethyl)(3,4-dicyanophenyl)amino]-N-methylbutanamide;

and 2-[(cyclopropylmethyl)(3,4-dicyanophenyl)amino]-N-ethylbutanamide.

7. A pharmaceutical composition comprising a compound according to claim 1 , and a pharmaceutically acceptable carrier.