Crystalline solid form of (2S,5Z)-2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid
(2S,5Z)-2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid is crystallized as an anhydrous, stoichiometric 1.5 HCl salt and a scaleable crystallization method is disclosed. The salt form was characterized and the absolute configuration of the chiral center was confirmed as “S”. (2S,5Z)-2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid was high melting and appears acceptably non-hygroscopic for use in a pharmaceutical composition.
1. A crystalline form of 2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid 1.5 hydrochloride characterized by at least one physical measurement selected from the group consisting of: x-ray powder diffraction pattern as shown in FIG. 3 , Raman spectrum as shown in FIG. 6 , melting point of 224° C. and a heat of fusion of 147 joules gram −1 .