IP Library Granted Patent US 7,060,018
Granted Patent B2
US 7,060,018 · App. 10/659,855 · Granted Jun 13, 2006

Centrifuge apparatus for processing blood

Assignee: COBE Cardiovascular, Inc.
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Quick Facts
Patent No.
US 7,060,018
App. No.
10/659,855
Granted
Jun 13, 2006
Kind
B2
Abstract

A centrifuge apparatus for processing blood comprising a bottom spring-loaded support plate; a top support plate; an axial inlet/outlet for blood to be processed and processed components of the blood, the axial inlet/outlet being attached to the top support plate by a rotating seal assembly; a variable volume separation chamber mounted between the bottom support plate and the top support plate, the variable volume separation chamber being fluidly connected to the axial inlet/outlet; a pump fluidly connected to the axial inlet/outlet; and a rotary drive unit attached to the bottom support plate. The top support plate is fixed vertically and the bottom spring-loaded support plate is mounted on springs that maintain pressure on the variable volume separation chamber and allow the bottom support plate to move vertically.

Claims (20)

1. A centrifuge apparatus for processing blood comprising:

a bottom support plate;

a top support plate;

an axial inlet/outlet for blood to be processed and processed components of the blood, the axial inlet/outlet being attached to the top support plate by a rotating seal assembly;

a variable volume separation chamber mounted between the bottom support plate and the top support plate, the variable volume separation chamber being fluidly connected to the axial inlet/outlet;

a pump fluidly connected to the axial inlet/outlet; and

a rotary drive unit attached to the bottom support plate,

wherein the top holder is fixed vertically and the bottom support plate is mounted on a mechanical actuator that maintains pressure on the variable volume separation chamber and allows the bottom support plate to move vertically, and

wherein the mechanical actuator is a ball-screw actuator.

2. An apparatus of claim 1 , wherein mechanical actuator is controlled automatically by a processing unit.

3. A centrifuge apparatus for processing blood comprising:

a bottom spring-loaded support plate;

a top support plate;

an axial inlet/outlet for blood to be processed and processed components of the blood, the axial inlet/outlet being attached to the top support plate by a rotating seal assembly;

a variable volume separation chamber mounted between the bottom support plate and the top support plate, the variable volume separation chamber being fluidly connected to the axial inlet/outlet;

a pump fluidly connected to the axial inlet/outlet; and

a rotary drive unit attached to the bottom support plate,

wherein the top support plate is fixed vertically and the bottom spring-loaded support plate is mounted on springs that maintain pressure on the variable volume separation chamber and allow the bottom support plate to move vertically, and

wherein a disposable cartridge has been mounted on the apparatus, the disposable cartridge comprising a plurality of ports for receiving or dispensing blood or blood components and a fluid sensor pathway for displaying blood or blood components for analysis, the cartridge being adapted to be mounted on a multi-position valve for directing flow between the ports and the fluid scnsor pathway being adapted to be mounted adjacent to one or more sensors for analyzing blood.

4. An apparatus of claim 3 , wherein the disposable cartridge snaps on to the apparatus.

Assignments (9)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 22, 2016
From: NUO THERAPEUTICS, INC. (F/K/A CYTOMEDIX, INC.)
To: DEERFIELD SS, LLC
Reel/Frame 039493/0795 →
ASSIGNMENT AND ASSUMPTION AGREEMENT Recorded Jun 29, 2016
From: NUO THERAPEUTICS, INC.
To: DEERFIELD SS, LLC
Reel/Frame 039209/0723 →
CHANGE OF NAME Recorded Feb 4, 2015
From: CYTOMEDIX, INC.
To: NUO THERAPEUTICS, INC.
Reel/Frame 034890/0806 →
RELEASE OF SECURITY INTEREST Recorded Apr 16, 2014
From: MIDCAP FUNDING III, LLC, AS AGENT
To: CYTOMEDIX, INC.; CYTOMEDIX ACQUISITION COMPANY, LLC; ALDAGEN, INC.
Reel/Frame 032684/0950 →
SECURITY INTEREST Recorded Apr 8, 2014
From: CYTOMEDIX, INC.; ALDAGEN, INC.; CYTOMEDIX ACQUISITION COMPANY, LLC
To: DEERFIELD PRIVATE DESIGN FUND II, L.P.; DEERFIELD PRIVATE DESIGN INTERNATIONAL II, L.P.; DEERFIELD SPECIAL SITUATIONS FUND, L.P.; DEERFIELD SPECIAL SITUATIONS INTERNATIONAL MASTER FUND, L.P.; DEERFIELD MGMT, L.P., AS AGENT
Reel/Frame 032629/0109 →
SECURITY AGREEMENT Recorded Feb 21, 2013
From: CYTOMEDIX, INC.; CYTOMEDIX ACQUISITION COMPANY, LLC; ALDAGEN, INC.
To: MIDCAP FUNDING III, LLC
Reel/Frame 029854/0298 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 20, 2012
From: SORIN GROUP USA, INC.
To: CYTOMEDIX, INC.
Reel/Frame 029509/0890 →
CHANGE OF NAME Recorded Dec 20, 2012
From: COBE CARDIOVASCULAR, INC.
To: SORIN GROUP USA, INC.
Reel/Frame 029530/0369 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 29, 2003
From: SKINKLE, DAVID W.; BERCH, STEPHEN W.
To: COBE CARDIOVASCULAR, INC.
Reel/Frame 014014/0812 →
Continuity (1)
Related Publication 20050059540A1 · Mar 17, 2005