Human immunodeficiency virus (HIV) gp41 peptide derivatives with enhanced solubility and antiviral activity
This invention relates to gp41 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to gp41 derivatives having inhibiting activity against human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) with enhanced duration of action for the treatment of the respective viral infections.
1. An isolated FB005, FB006 or FB066 peptide comprising the sequence of SEQ ID NO:1, SEQ ID NO:2 or SEQ ID NO: 7, respectively.
2. An isolated peptide derivatized with a maleimide linking moiety, selected from the group consisting of:
(a) the FB005M peptide of SEQ ID NO:8;
(b) the FB005CM peptide of SEQ ID NO:9;
(c) the FB006M peptide of SEQ ID NO:10;
(d) the FB007M peptide of SEQ ID NO:11;
(e) the FB066M peptide of SEQ ID NO:14; and
(f) the FB066KM peptide of SEQ ID NO:15.
3. An isolated, derivatized peptide selected from the group consisting of:
(a) SEQ ID NO:1;
(b) SEQ ID NO:2; and
(c) SEQ ID NO:7,
wherein predetermined amino acid residues in the peptide sequence are derivatized by conjugating a coupling group to said predetermined amino acid residues.