IP Library Granted Patent US 7,267,838
Granted Patent B2
US 7,267,838 · App. 10/675,804 · Granted Sep 11, 2007

Method for applying a film of sample to a sample carrier

Assignee: Bruker BioSpin, GmbH
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Quick Facts
Patent No.
US 7,267,838
App. No.
10/675,804
Granted
Sep 11, 2007
Kind
B2
Abstract

A method for applying a sample film to a sample carrier for subsequent spectroscopic analysis is described, comprising providing a quantity of sample in liquid state, providing a sample carrier having at least one sample position, applying the quantity of sample in liquid state on the at least one sample position in a plurality of partial quantities of the quantity of sample in such a manner that the partial quantities on the at least one sample position are not in contact with one another before being dried, drying the quantity of sample to form the sample film.

Claims (22)

1. A method of optical spectroscopy of samples, comprising the steps of:

providing a quantity of sample in liquid state; providing a sample carrier having at least one sample position;

applying said quantity of sample in liquid state on said at least one sample position in a plurality of partial quantities of said quantity of sample across a measurement area of said at least one sample position in such a manner that said partial quantities across said measurement area of said at least one sample position are not in contact with one another before being dried;

drying said quantity of sample to form a sample film across said measurement area; and

spectroscopically analyzing said sample film across said measurement area employing at least one of infrared spectroscopy, near infrared spectroscopy and Raman spectroscopy.

2. The method of claim 1 , wherein said partial quantities of said quantity of sample are applied across said measurement area of said at least one sample position in form of a grid with a maximum occupation density.

3. The method of claim 1 , wherein said partial quantities amount to from about 1/10,000 to about 1/10 of said quantity of sample to be applied to said at least one sample position.

4. The method of claim 1 , wherein said applying said quantity of sample in liquid state across said measurement area of said at least one sample position comprises first applying a first layer of said partial quantities to said at least one sample position, drying said first layer and applying at least one further layer of partial quantities of said quantity of sample to said at least one sample position and drying said at least one further layer of partial quantities.

5. The method of claim 4 , further comprising applying said partial quantities belonging to said at least one further layer to said at least one sample position such that said partial quantities of said at least one further layer are offset with respect to positions of said partial quantities belonging to said first layer.

6. The method of claim 5 , further comprising heating said sample carrier.

7. The method of claim 5 , wherein said plate is made from infrared (IR)-transparent material.

8. The method of claim 5 , wherein a metal plate whose surface is roughened is used as said sample carrier.

9. The method of claim 5 , wherein said sample carrier is used as a sample carrier having a plurality of sample positions.

10. The method of claim 1 , wherein said applying said quantity of sample in liquid state on said at least one sample position comprises first applying a first layer of said partial quantities to said at least one sample position, drying said first layer and applying at least one further layer of partial quantities of said quantity of sample to said at least one sample position and drying said at least one further layer of partial quantities, wherein said partial quantities belonging to said at least one further layer are applied to positions of said partial quantities belonging to said first layer.

11. The method of claim 10 , further comprising heating said sample carrier.

12. The method of claim 10 , wherein a plate made from infrared transparent material is used as said sample carrier.

13. The method of claim 10 , wherein a metal plate whose surface is roughened is used as said sample carrier.

14. The method of claim 10 , wherein said sample carrier is used as a sample carrier having a plurality of sample positions.

15. The method of claim 1 , further comprising heating said sample carrier.

16. The method of claim 1 , wherein a plate made from infrared (IR)-transparent material is used as said sample carrier.

17. The method of claim 1 , wherein a metal plate whose surface is roughened is used as said sample carrier.

18. The method of claim 1 , wherein said sample carrier is used as a sample carrier having a plurality of sample positions.

Assignments (2)
NUNC PRO TUNC ASSIGNMENT Recorded Feb 18, 2022
From: BRUKER OPTIK GMBH
To: BRUKER OPTICS GMBH & CO. KG
Reel/Frame 059049/0058 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 12, 2004
From: BOESE, MATTHIAS
To: BRUKER OPTIK GMBH
Reel/Frame 014974/0407 →
Priority Claims (1)
DE 102 46 446 · Oct 4, 2002 · national
Continuity (1)
Related Publication 20040113072A1 · Jun 17, 2004