Tumor inhibiting gallium compounds
View Patent ↗The invention relates to a compound of the general formula (I) where R 1 , R 2 , R 3 , R 4 , R 1 ′, R 2 ′, R 3 ′ and R 4 ′ are independently of one another hydrogen, C 1 –C 15 -alkyl, C 2 –C 15 -alkenyl, C 2 –C 15 -alkinyl, C 3 –C 16 -cycloalkyl, C 3 –C 16 -cycloalkenyl, aryl or a heterocyclus which in each case can be substituted or unsubstituted, Y is a physiologically compatible anion, and n is 1 or 2, as well as its application to the prophylaxis and/or tretment of cancer illnesses.
1. A compound of the general formula (I)
where
R 1 , R 2 , R 3 , R 4 , R 1 ′, R 2 ′, R 3 ′ and R 4 ′ are independently of one another hydrogen, C 1 –C 15 -alkyl, C 2 –C 15 -alkenyl, C 2 –C 15 -alkinyl, C 3 –C 16 -cycloalkyl, C 3 –C 16 -cycloalkenyl, aryl or a heterocyclus which in each case can be substituted or unsubstituted,
Y is a physiologically compatible anion, and
n is 1 or 2.
2. A compound according to claim 1 , where Y is [GaCl 4 ].
3. A medicament containing a compound of the general formula (I) according to claim 1 .
4. A medicament containing a compound of the general formula (I) according to claim 2 .
5. A method of treatment of a cancer illness, the method comprising administering a compound of claim 1 to a living organism, wherein the cancer illness comprises at least one of adenocarcinoma of the colon, teratocarcinoma of the testis, mammary carcinoma, prostrate carcinoma, macrocellular bronchial carcinoma, stomach carcinoma, melanoma xenograft, ovarian carcinoma and parvicellular bronchial carcinoma.
6. The method of claim 5 , wherein the living organism is a human.
7. A method of treatment of a cancer illness, the method comprising administering a compound of claim 2 to a living organism.
8. The method of claim 7 , wherein the living organism is a human.
9. A method of treatment of a cancer illness, the method comprising:
producing a medicament comprising a compound of claim 1 ; and
administering the medicament to a living organism,
wherein the cancer illness comprises at least one of adenocarcinoma of the colon, teratocarcinoma of the testis, mammary carcinoma, prostrate carcinoma, macrocellullar bronchial carcinoma, stomach carcinoma, melanoma xenograft, ovarian carcinoma and parvicellular bronchial carcinoma.
10. The method of claim 9 , wherein the living organism is a human.
11. A method of treatment of a cancer illness, the method comprising:
producing a medicament comprising a compound of claim 2 ; and
administering the medicament to a living organism.
12. The method of claim 11 , wherein the living organism is a human.
13. The method of claim 5 , wherein the cancer illness comprises adenocarcinoma of the colon.
14. The method of claim 5 , wherein the cancer illness comprises teratocarcinoma of the testis.
15. The method of claim 5 , wherein the cancer illness comprises at least one of mammary carcinoma, prostrate carcinoma and macrocellular bronchial carcinoma.
16. The method of claim 5 , wherein the cancer illness comprises at least one of stomach carcinoma, melanoma xenograft, ovarian carcinoma and parvicellular bronchial carcinoma.
17. The method of claim 9 , wherein the cancer illness comprises adenocarcinoma of the colon.
18. The method of claim 9 , wherein the cancer illness comprises teratocarcinoma of the testis.
19. The method of claim 9 , wherein the cancer illness comprises at least one of mammary carcinoma, prostrate carcinoma and macrocellular bronchial carcinoma.
20. The method of claim 9 , wherein the cancer illness comprises at least one of stomach carcinoma, melanoma xenograft, ovarian carcinoma and parvicellular bronchial carcinoma.