Gene SCC-112 and diagnostic and therapeutic uses thereof
A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. SCC-112 (about 150 kDa) and/or a mutant form of SCC-112 (about 65 kDa) is a tumor suppressor molecule. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SCC-112 such as breast and kidney cancers.
1. An isolated nucleic acid molecule having the nucleic acid sequence consisting essentially of that set forth in SEQ ID NO: 1.
2. An isolated nucleic acid molecule encoding the amino acid sequence consisting essentially of that set forth in SEQ ID NO: 2.
3. The isolated nucleic acid molecule of claim 1 , which is DNA.
4. The isolated nucleic acid molecule of claim 2 , which is DNA.
5. A method of making a recombinant vector comprising inserting a nucleic acid molecule of any of claims 1 , 2 , 3 or 4 into a vector in operable linkage to a promoter.
6. A recombinant vector produced by the method of claim 5 .
7. A method of making a recombinant host cell comprising introducing the recombinant vector of claim 6 into a host cell.
8. A recombinant host cell produced by the method of claim 7 .
9. A recombinant method of producing a polypeptide, comprising culturing the recombinant host cell of claim 8 under conditions such that said polypeptide is expressed and recovering said polypeptide.