IP Library › Granted Patent US 7,255,860
Granted Patent B2
US 7,255,860 · App. 10/682,638 · Granted Aug 14, 2007

Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody

Assignee: Rinat Neuroscience Corp.
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Quick Facts
Patent No.
US 7,255,860
App. No.
10/682,638
Granted
Aug 14, 2007
Kind
B2
Abstract

The invention features methods and compositions for preventing or treating post-surgical pain by administering an anti-NGF antagonist antibody.

Claims (11)

1. A method for treating post-surgical pain in a human subject comprising administering to the subject in need of such treatment an effective amount of an anti-nerve growth factor (NGF) antagonist antibody, whereby the post-surgical pain in the subject is treated.

2. The method of claim 1 , wherein the post-surgical pain comprises resting pain, and wherein the resting pain is ameliorated.

3. The method of claim 1 , wherein the post-surgical pain comprises mechanically-induced pain, and wherein the mechanically-induced pain is ameliorated.

4. The method of claim 1 , wherein the anti-NGF antagonist antibody is a human antibody.

5. The method of claim 1 , wherein the anti-NGF antagonist antibody is a humanized antibody.

6. The method of claim 1 , wherein the anti-NGF antagonist antibody binds human NGF.

7. The method of claim 6 , wherein the anti-NGF antagonist antibody binds human NGF with a binding affinity of about 0.1 nM or less than about 0.1 nM.

8. The method of claim 1 , wherein the post-surgical pain comprises resting pain and mechanically-induced pain, and wherein the resting pain and mechanically-induced pain are ameliorated.

9. The method of claim 1 , wherein the post-surgical pain comprises thermally-induced pain, and wherein the thermally-induced pain is ameliorated.

10. The method of claim 1 , wherein the post-surgical pain comprises resting pain, mechanically-induced pain, and thermally-induced pain, and wherein the resting pain, mechanically-induced pain, and thermally-induced pain are ameliorated.

11. The method of claim 1 , wherein wound healing is not significantly inhibited.

Assignments (2)
ASSIGNEE ADDRESS CHANGE Recorded Mar 22, 2023
From: RINAT NEUROSCIENCE CORP.
To: RINAT NEUROSCIENCE CORP.
Reel/Frame 063143/0806 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 23, 2004
From: SHELTON, DAVID L.; VERGARA, GERMAN J.
To: RINAT NEUROSCIENCE CORP.
Reel/Frame 014771/0169 →
Continuity (2)
Provisional Application 6041719700 · Oct 8, 2002
Related Publication 20070160605A1 · Jul 12, 2007