Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody
The invention features methods and compositions for preventing or treating post-surgical pain by administering an anti-NGF antagonist antibody.
1. A method for treating post-surgical pain in a human subject comprising administering to the subject in need of such treatment an effective amount of an anti-nerve growth factor (NGF) antagonist antibody, whereby the post-surgical pain in the subject is treated.
2. The method of claim 1 , wherein the post-surgical pain comprises resting pain, and wherein the resting pain is ameliorated.
3. The method of claim 1 , wherein the post-surgical pain comprises mechanically-induced pain, and wherein the mechanically-induced pain is ameliorated.
4. The method of claim 1 , wherein the anti-NGF antagonist antibody is a human antibody.
5. The method of claim 1 , wherein the anti-NGF antagonist antibody is a humanized antibody.
6. The method of claim 1 , wherein the anti-NGF antagonist antibody binds human NGF.
7. The method of claim 6 , wherein the anti-NGF antagonist antibody binds human NGF with a binding affinity of about 0.1 nM or less than about 0.1 nM.
8. The method of claim 1 , wherein the post-surgical pain comprises resting pain and mechanically-induced pain, and wherein the resting pain and mechanically-induced pain are ameliorated.
9. The method of claim 1 , wherein the post-surgical pain comprises thermally-induced pain, and wherein the thermally-induced pain is ameliorated.
10. The method of claim 1 , wherein the post-surgical pain comprises resting pain, mechanically-induced pain, and thermally-induced pain, and wherein the resting pain, mechanically-induced pain, and thermally-induced pain are ameliorated.
11. The method of claim 1 , wherein wound healing is not significantly inhibited.