Pharmaceutical compositions including low dosages of desmopressin
The present invention is directed to a pharmaceutical composition comprising 0.5 ng to 20 μg desmopressin and a pharmaceutically acceptable carrier. The present invention is also directed to a pharmaceutical composition comprising desmopressin and a pharmaceutically acceptable carrier, wherein the pharmaceutical composition is effective to establish a steady plasma/serum desmopressin concentration in the range of from about 0.1 picograms desmopressin per mL plasma/serum to about 10.0 picogram desmopressin per mL plasma/serum. Articles of manufacture and methods of using the above invention are also disclosed.
1. A pharmaceutical composition comprising desmopressin and a pharmaceutically acceptable carrier in a dosage form which dispenses by intranasal, transdermal, or intradermal administration from 0.5 ng up to 1 μg desmopressin.
2. The pharmaceutical composition of claim 1 in a dosage form comprising a patch, gel, cream, ointment, or iontophore adapted for transdermal delivery.
3. The pharmaceutical composition of claim 1 in a dosage form comprising a patch adapted for intradermal administration.
4. The pharmaceutical composition of claim 1 in a dosage form comprising a spray adapted for intranasal delivery.
5. The pharmaceutical composition of claim 1 in a dosage form sufficient to establish in a patient a steady plasma/serum desmopressin concentration of from about 0.1 picograms desmopressin per mL plasma/serum to 10 picograms desmopressin per mL plasma/serum.
6. The pharmaceutical composition of claim 1 in a dosage form sufficient to establish in a patient a steady plasma/serum desmopressin concentration of from about 0.5 picograms desmopressin per mL plasma/serum to about 5.0 picograms desmopressin per mL plasma/serum.
7. A pharmaceutical composition comprising desmopressin and a pharmaceutically acceptable carrier in a dosage form adapted for intranasal administration which dispenses from 0.1 ng up to 1 μg desmopressin and which when administered to a patient establishes a steady plasma/serum desmopressin concentration in the range of from about 0.1 picograms desmopressin per mL plasma/serum to about a maximum of 10.0 picograms desmopressin per mL plasma/serum and decreases urine production.
8. The composition of claim 7 which establishes a steady plasma/serum desmopressin concentration of from about 0.5 picograms desmopressin per mL plasma/serum to about 5.0 picograms desmopressin per mL plasma/serum.
9. A pharmaceutical composition comprising desmopressin and a pharmaceutically acceptable carrier in a dosage form adapted for intradermal or transdermal administration which dispenses from 0.1 ng up to 1 μg desmopressin and which when administered to a patient establishes a steady plasma/serum desmopressin concentration in the range of from about 0.1 picograms desmopressin per mL plasma/serum to about a maximum of 10.0 picograms desmopressin per mL plasma/serum and decreases urine production.
10. The dosage form of claim 9 which establishes a steady plasma/serum desmopressin concentration of from about 0.5 picograms desmopressin per mL plasma/serum to about 5.0 picograms desmopressin per mL plasma/serum.
11. The dosage form of claim 9 adapted for intradermal administration comprising a patch.
12. The dosage form of claim 9 adapted for transdermal delivery and comprising a patch, gel, cream, ointment, or iontophore.
13. The composition of claim 1 which establishes said plasma/serum desmopressin concentration range for a time between four and six hours.
14. The composition of claim 7 which establishes said plasma/serum desmopressin concentration range for a time between four and six hours.
15. The composition of claim 8 which establishes said plasma/serum desmopressin concentration range for a time between four and six hours.
16. The composition of claim 9 which establishes said plasma/serum desmopressin concentration range for a time between four and six hours.
17. The composition of claim 10 which establishes said plasma/serum desmopressin concentration range for a time between four and six hours.