Methods for treating prostatic intraepithelial neoplasia with herbal compositions

1. A method for treating prostatic intraepithelial neoplasia in a subject, comprising the step of administering an effective amount of a composition to said subject to treat said prostatic intraepithelial neoplasia, said composition comprising therapeutically effective amounts of supercritical extracts of rosemary, turmeric, oregano and ginger; and therapeutically effective amounts of hydroalcoholic extracts of holy basil, ginger, turmeric, Scutellaria baicalensis , rosemary, green tea, huzhang, Chinese goldthread, and barberry.

2. The method of claim 1 , wherein said composition is administered orally.

3. The method of claim 2 , wherein the orally administered composition is in the form of one or more capsules, one or more tablets, or one or more pills.

4. The method of claim 1 , wherein the composition comprises:

(A) from about 4.5% to about 7.5% by weight of the hydroalcoholic extract of ginger;

(B) from about 5.5% to about 8.5% by weight of the supercritical extract of ginger;

(C) from about 1.0% to about 1.5% by weight of the supercritical extract of turmeric;

(D) from about 10.0% to about 16.0% by weight of the supercritical extract of rosemary;

(E) from about 4.0% to about 6.0% by weight of the supercritical extract of oregano;

(F) from about 10.0% to about 16.0% by weight of the hydroalcoholic extract of turmeric;

(G) from about 5.5% to about 8.0% by weight of the hydroalcoholic extract of rosemary;

(H) from about 10.0% to about 16.0% by weight of the hydroalcoholic extract of holy basil;

(I) from about 10.0% to about 16.0% by weight of the hydroalcoholic extract of green tea;

(J) from about 8.0% to about 12.0% by weight of the hydroalcoholic extract of huzhang;

(K) from about 4.0% to about 6.0% by weight of the hydroalcoholic extract of Chinese goldthread;

(L) from about 4.0% to about 6.0% by weight of the hydroalcoholic extract of barberry; and

(M) from about 2.0% to about 3.0% by weight of the hydroalcoholic extract of Scutellaria baicalensis.

5. The method of claim 1 , wherein the weight ratio of the supercritical extract of ginger to the hydroalcoholic extract of ginger is from about 0.9:1 toabout 1.4:1.

6. The method of claim 1 , wherein the weight ratio of the hydroalcoholic extract of turmeric to the supercritical extract of turmeric is from about 8:1 to about 12:1.

7. The method of claim 1 , wherein the weight ratio of the supercritical extract of rosemary to the hydroalcoholic extract of rosemary is from about 1.6:1 to about 2.4:1.

8. The method of claim 1 , wherein the hydroalcoholic extract of ginger comprises from about 2.4% to about 3.6% by weight of pungent compounds.

9. The method of claim 1 , wherein the supercritical extract of ginger comprises from about 24% to about 36% by weight of pungent compounds and from about 6.4% to about 9.6% by weight of zingiberene.

10. The method of claim 1 , wherein the supercritical extract of turmeric comprises from about 36% to about 54% by weight of turmerones.

11. The method of claim 1 , wherein the supercritical extract of rosemary comprises from about 18.4% to about 27.6% by weight of total phenolic antioxidants.

12. The method of claim 1 , wherein the supercritical extract of oregano comprises from about 0.64% to about 0.96% by weight of total phenolic antioxidants.

13. The method of claim 1 , wherein the hydroalcoholic extract of turmeric comprises from about 5.6% to about 8.4% by weight of curcumin.

14. The method of claim 1 , wherein the hydroalcoholic extract of rosemary comprises from about 18.4% to about 27.6% by weight of total phenolic antioxidants.

15. The method of claim 1 , wherein the hydroalcoholic extract of holy basil comprises from about 1.6% to about 2.4% by weight of ursolic acid.

16. The method of claim 1 , wherein the hydroalcoholic extract of green tea comprises from about 36% to about 54% by weight of polyphenols.

17. The method of claim 1 , wherein the hydroalcoholic extract of huzhang comprises from about 6.4% to about 9.6% by weight of resveratrol.

18. The method of claim 1 , wherein the hydroalcoholic extract of Chinese goldthread comprises from about 4.8% to about 7.2% by weight of berberine.

19. The method of claim 1 , wherein the hydroalcoholic extract of barberry comprises from about 4.8% to about 7.2% by weight of berberine.

20. The method of claim 1 , wherein said composition provided in step (a) comprises:

(A) from about 4.5% to about 7.5% by weight of the hydroalcoholic extract of ginger, wherein the extract comprises from about 2.4% to about 3.6% by weight of pungent compounds;

(B) from about 5.5% to about 8.5% by weight of the supercritical extract of ginger, wherein the extract comprises from about 24% to about 36% by weight of pungent compounds and from about 6.4% to about 9.6% by weight of zingiberene;

(C) from about 1.0% to about 1.5% by weight of the supercritical extract of turmeric, wherein the extract comprises from about 36% to about 54% by weight of turmerones;

(D) from about 10.0% to about 16.0% by weight of the supercritical extract of rosemary, wherein the extract comprises from about 18.4% to about 27.6% by weight of total phenolic antioxidants;

(E) from about 4.0% to about 6.0% by weight of the supercritical extract of oregano, wherein the extract comprises from about 0.64% to about 0.96% by weight of total phenolic antioxidants;

(F) from about 10.0% to about 16.0% by weight of the hydroalcoholic extract of turmeric, wherein the extract comprises from about 5.6% to about 8.4% by weight of curcumin;

(G) from about 5.5% to about 8.0% by weight of the hydroalcoholic extract of rosemary, wherein the extract comprises from about 18.4% to about 27.6% by weight of total phenolic antioxidants;

(H) from about 10.0% to about 16.0% by weight of the hydroalcoholic extract of holy basil, wherein the extract comprises from about 1.6% to about 2.4% by weight of ursolic acid;

(I) from about 10.0% to about 16.0% by weight of the hydroalcoholic extract of green tea, wherein the extract comprises from about 36% to about 54% by weight of polyphenols;

(J) from about 8.0% to about 12.0% by weight of the hydroalcoholic extract of huzhang, wherein the extract comprises from about 6.4% to about 9.6% by weight of resveratrol;

(K) from about 4.0% to about 6.0% by weight of the hydroalcoholic extract of Chinese goldthread, wherein the extract from about 4.8% to about 7.2% by weight of berberine;

(L) from about 4.0% to about 6.0% by weight of the hydroalcoholic extract of barberry, wherein the extract from about 4.8% to about 7.2% by weight of berberine; and

(M) from about 2.0% to about 3.0% by weight of the hydroalcoholic extract of Scutellaria baicalensis;

and wherein said composition further comprises:

(i) the supercritical extract of ginger and the hydroalcoholic extract of ginger at a weight ratio of from about 0.9 to about 1.4 parts of supercritical extract per 1 part of hydroalcoholic extract;

(ii) the hydroalcoholic extract of turmeric and the supercritical extract of turmeric at a weight ratio of from about 8 to about 12 parts of hydroalcoholic extract per 1 part of supercritical extract; and

(iii) the supercritical extract of rosemary and the hydroalcoholic extract of rosemary at a weight ratio of from about 1.6 to about 2.4 parts of supercritical extract per 1 part of hydroalcoholic extract.

21. The method of claim 1 , said composition is administered in a daily dosage of at least about 700 mg.

22. The method of claim 1 , wherein said composition is administered on a daily basis for at least 4 weeks.

23. A method for treating precancerous cellular proliferations within prostatic ducts, ductiles and acini in a subject, comprising the step of administering an effective amount of a composition to said subject to treat said precancerous cellular proliferations, said composition comprising therapeutically effective amounts of supercritical extracts of rosemary, turmeric, oregano and ginger; and therapeutically effective amounts of hydroalcoholic extracts of holy basil, ginger, turmeric, Scutellaria baicalensis , rosemary, green tea, huzhang, Chinese goldthread, and barberry.

24. The method of claim 23 , wherein said composition is administered orally.

25. The method of claim 24 , wherein the orally administered composition is in the form of one or more capsules, one or more tablets, or one or more pills.

26. The method of claim 23 , wherein the composition comprises:

(A) from about 4.5% to about 7.5% by weight of the hydroalcoholic extract of ginger;

(B) from about 5.5% to about 8.5% by weight of the supercritical extract of ginger;

(C) from about 1.0% to about 1.5% by weight of the supercritical extract of turmeric;

(D) from about 10.0% to about 16.0% by weight of the supercritical extract of rosemary;

(E) from about 4.0% to about 6.0% by weight of the supercritical extract of oregano;

(F) from about 10.0% to about 16.0% by weight of the hydroalcoholic extract of turmeric;

(G) from about 5.5% to about 8.0% by weight of the hydroalcoholic extract of rosemary;

(H) from about 10.0% to about 16.0% by weight of the hydroalcoholic extract of holy basil;

(I) from about 10.0% to about 16.0% by weight of the hydroalcoholic extract of green tea;

(J) from about 8.0% to about 12.0% by weight of the hydroalcoholic extract of huzhang;

(K) from about 4.0% to about 6.0% by weight of the hydroalcoholic extract of Chinese goldthread;

(L) from about 4.0% to about 6.0% by weight of the hydroalcoholic extract of barberry; and

(M) from about 2.0% to about 3.0% by weight of the hydroalcoholic extract of Scutellaria baicalensis.

27. The method of claim 23 , wherein the weight ratio of the supercritical extract of ginger to the hydroalcoholic extract of ginger is from about 0.9:1 to about 1.4:1.

28. The method of claim 23 , wherein the weight ratio of the hydroalcoholic extract of turmeric to the supercritical extract of turmeric is from about 8:1 to about 12:1.

29. The method of claim 23 , wherein the weight ratio of the supercritical extract of rosemary to the hydroalcoholic extract of rosemary is from about 1.6:1 to about 2.4:1.

30. The method of claim 23 , wherein the post supercritical hydroalcoholic extract of ginger comprises from about 2.4% to about 3.6% by weight of pungent compounds.

31. The method of claim 23 , wherein the supercritical extract of ginger comprises from about 24% to about 36% by weight of pungent compounds and from about 6.4% to about 9.6% by weight of zingiberene.

32. The method of claim 23 , wherein the supercritical extract of turmeric comprises from about 36% to about 54% by weight of turmerones.

33. The method of claim 23 , wherein the supercritical extract of rosemary comprises from about 18.4% to about 27.6% by weight of total phenolic antioxidants.

34. The method of claim 23 , wherein the supercritical extract of oregano comprises from about 0.64% to about 0.96% by weight of total phenolic antioxidants.

35. The method of claim 23 , wherein the hydroalcoholic extract of turmeric comprises from about 5.6% to about 8.4% by weight of curcumin.

36. The method of claim 23 , wherein the hydroalcoholic extract of rosemary comprises from about 18.4% to about 27.6% by weight of total phenolic antioxidants.

37. The method of claim 23 , wherein the hydroalcoholic extract of holy basil comprises from about 1.6% to about 2.4% by weight of ursolic acid.

38. The method of claim 23 , wherein the hydroalcoholic extract of green tea comprises from about 36% to about 54% by weight of polyphenols.

39. The method of claim 23 , wherein the hydroalcoholic extract of huzhang comprises from about 6.4% to about 9.6% by weight of resveratrol.

40. The method of claim 23 , wherein the hydroalcoholic extract of Chinese goldthread comprises from about 4.8% to about 7.2% by weight of berberine.

41. The method of claim 23 , wherein the hydroalcoholic extract of barberry comprises from about 4.8% to about 7.2% by weight of berberine.

42. The method of claim 23 , said composition is administered in a daily dosage of at least about 700 mg.

43. The method of claim 23 , wherein said composition is administered on a daily basis for at least 4 weeks.