Oral drug delivery system
Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
1. An oral formulation comprising:
a drug selected from the group consisting of buprenorphine, butorphanol, hydrocodone, hydromorphone, levorphanol, meperidine, methadone, morphine, oxycodone, oxymorphone, and tramadol, or pharmacologically effective salts thereof;
sucrose acetate isobutyrate (SAIB);
a cellulose acetate butyrate (CAB) having a number average molecular weight ranging from 66,000 Daltons to 83,000 Daltons;
isopropyl myristate (IPM); and
a solvent in which the CAB is soluble.
2. The oral formulation of claim 1 , wherein the solvent is triacetin or ethyl lactate.
3. The oral formulation of claim 1 , wherein the solvent is triacetin.
4. The oral formulation of claim 1 , wherein the solvent comprises propylene carbonate, N-methylpyrrolidone (NMP), glycofurol, alpha-tocopherol, diethyl phthalate, or polyethylene glycol 400 (PEG 400).
5. The oral formulation of claim 1 , wherein the CAB has a butyryl content ranging from about 17% to about 38%.
6. The oral formulation of claim 1 , wherein the CAB has an acetyl content ranging from about 13% to about 30%.
7. The oral formulation of claim 1 , wherein the CAB has a hydroxyl content ranging from about 0.8% to about 1.7%.
8. The oral formulation of claim 1 , wherein the CAB has a butyryl content ranging from about 17% to about 38%, an acetyl content ranging from about 13% to about 30%, and a hydroxyl content ranging from about 0.8% to about 1.7%.
9. The oral formulation of claim 1 , wherein the formulation comprises from about 1 to about 8.6 weight percent of the CAB.
10. The oral formulation of claim 9 , wherein the drug is hydrocodone, hydromorphone, levorphanol, morphine, oxymorphone or oxycodone.
11. The oral formulation of claim 9 , wherein the drug is oxycodone.
12. The oral formulation of claim 1 , wherein the formulation comprises from about 20 to about 50 weight percent of the solvent.
13. The oral formulation of claim 1 , wherein the formulation comprises from about 1 to about 75 weight percent IPM.
14. An oral dosage form comprising the formulation of claim 1 , wherein the formulation is contained in a capsule.
15. The oral dosage form of claim 14 , wherein the capsule comprises gelatin or hydroxyl propylmethyl cellulose.
16. The oral dosage form of claim 14 , wherein the capsule is a hard capsule comprising gelatin or hydroxyl propylmethyl cellulose.
17. A method of treating a subject, the method comprising:
orally administering to the subject an effective amount of the oral dosage form of claim 14 .
18. The oral formulation of claim 1 , wherein the formulation comprises:
from about 1 to about 8.6 weight percent of the CAB;
from about 20 to about 50 weight percent of the solvent; and
from about 1 to about 75 weight percent IPM.
19. The oral formulation of claim 18 , wherein the formulation comprises from 3 to 7.8 weight percent of the CAB.
20. The oral formulation of claim 19 , wherein the CAB has a butyryl content ranging from about 17% to about 38%.
21. The oral formulation of claim 19 , wherein the CAB has an acetyl content ranging from about 13% to about 30%.
22. The oral formulation of claim 19 , wherein the CAB has a hydroxyl content ranging from about 0.8% to about 1.7%.
23. The oral formulation of claim 19 , wherein the CAB has a butyryl content ranging from about 17% to about 38%, an acetyl content ranging from about 13% to about 30%, and a hydroxyl content ranging from about 0.8% to about 1.7%.
24. The oral formulation of claim 23 , wherein the solvent is triacetin.
25. The oral formulation of claim 24 , wherein the drug is oxycodone.
26. An oral dosage form comprising the formulation of claim 18 , wherein the formulation is contained in a capsule.
27. The oral dosage form of claim 26 , wherein the capsule comprises gelatin or hydroxyl propylmethyl cellulose.
28. The oral dosage form of claim 27 , wherein the capsule is a hard capsule comprising gelatin or hydroxyl propylmethyl cellulose.
29. A method of treating a subject, the method comprising:
orally administering to the subject an effective amount of the oral formulation of claim 1 .