Inhibitors of the inositol polyphosphate 5-phosphatase SHIP2 molecule
The present invention is related to an inhibitor of the inositol polyphosphate 5-phosphatase SHIP2 protein or its encoding nucleotide sequence identified by SEQ ID NO. 1 or of SHIP2 mRNA expression. The present invention is also related to a pharmaceutical composition comprising said inhibitor and an adequate pharmaceutically acceptable carrier or diluent and to a non-human knock-out mammal comprising homozygously or heterozygously a partial or total deletion in its genome of the inositol polyphoshate 5-phosphatase SHIP2 nucleotide sequence.
1 . A transgenic knock-out non-human mammal comprising disruption in the endogenous inositol polyphosphate 5-phosphatase gene encoding a protein of SEQ ID No. 1.
2 . The transgenic mammal of claim 1 , wherein said disruption comprises a partial or total deletion of an inositol polyphosphate 5-phosphatase nucleotide sequence encoding a protein of SEQ ID No. 1.
3 . The transgenic mammal of claim 1 , wherein said disruption is homozygously or heretozygously.
4 . The transgenic mammal of claim 1 , wherein said mammal is a transgenic knock-out mouse.
5 . The transgenic knock-out mouse of claim 4 , exhibiting postnatal hypoglycaemia and/or hypersensitivity to insulin signalling.