Methods and unit dose formulations for the inhalation administration of tobramycin
A patient suffering from an endobronchial infection is treated by administering to the patient for inhalation a dose of less than about 4.0 ml of a nebulized aerosol formulation comprising from about 60 to about 200 mg/ml of an aminoglycoside antibiotic, such as tobramycin, in a physiologically acceptable carrier in a time period of less than about 10 minutes. Unit dose devices for storage and delivery of the aminoglycoside antibiotic formulations are also provided.
1. A method of treatment of a patient having an endobronchial infection comprising administering to the patient for inhalation a nebulized unit dose of 4.0 ml or less of an aqueous solution comprising from about 60 to about 200 mg/ml of tobramycin in a physiologically acceptable carrier for a duration of nebulization less than about 10 minutes, using an inhalation device having a rate of aerosol output of not less than about 4 μl/sec, that releases at least about 75% of the loaded dose, and that produces aerosol particles having particle sizes between about 1 μm to about 5 μm.
2. A method of claim 1 wherein the unit dose comprises less than about 3.75 ml. of the aqueous solution.
3. A method of claim 1 wherein the unit dose comprises 3.75 ml. or less of the aqueous solution.
4. A method of claim 1 wherein the aqueous solution comprises from about 80 to about 180 mg./ml. of tobramycin.
5. A method of claim 1 wherein the aqueous solution comprises from about 90 to about 150 mg./ml. of tobramycin.
6. A method of claim 1 wherein the unit dose comprises 3.75 ml. or less of an aqueous solution comprising from about 80 to about 180 mg./ml. of tobramycin.
7. A method of claim 1 wherein the duration of nebulization is less than about 8 minutes.
8. A method of claim 1 wherein the duration of nebulization is less than about 6 minutes.
9. A method of claim 1 wherein the inhalation device is breath actuated.
10. A method of claim 1 wherein the inhalation device has a rate of aerosol output of not less than about 5 μl/sec.
11. A method of claim 1 wherein the inhalation device has a rate of aerosol output of not less than about 8 μl/sec.
12. A method of claim 1 wherein the inhalation device releases at least about 80 percent of the loaded dose.
13. A method of claim 1 wherein the inhalation device releases at least about 85 percent of the loaded dose.
14. A method of the treatment of a patient having an endobronchial infection comprising administering to the patient for inhalation a nebulized unit dose of 3.5 ml or less of an aqueous solution comprising from about 90 to 150 mg/ml of tobramycin in a physiologically acceptable carrier for a duration of nebulization less than about 6 minutes, using an inhalation device having a rate of aerosol output of not less than about 4 μl/sec, that releases at least about 75% of the loaded dose, and that produces aerosol particles having a particle size of about 1 μm to about 5 μm.