Antibodies specific for plasmacytoid dendritic cells
View Patent ↗The invention provides immunological reagents (antibodies) capable of binding to plasmacytoid dendritic cells (pDC), to cell lines which express such antibodies and to a process for identifying and purifying plasmacytoid dendriticcells from tissues containing pDC using such antibodies.
1. A hybridoma cell line deposited as ATCC Accession No. PTA-4957.
2. An antibody produced by the hybridoma cell line of claim 1 .
3. The antibody of claim 2 , wherein said antibody is a monoclonal antibody.
4. An antigen binding fragment of the antibody of claim 2 .
5. A method for purifying murine plasmacytoid dendritic cells from a sample, said method comprising the steps of contacting said sample with the antibody of claim 2 , and recovering said cells that are bound to said antibody.
6. A method for identifying murine plasmacytoid dendritic cells from a sample, said method comprising the steps of contacting said sample with the antibody of claim 2 to form an antibody/plasmacytoid dendritic cell complex, and detecting said complex.