IP Library › Granted Patent US 7,323,551
Granted Patent B2
US 7,323,551 · App. 10/766,317 · Granted Jan 29, 2008

Compositions and methods for inhibiting squamous cell carcinoma

Assignee: The Board of Trustees of the Leland Stanford Junior University
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Quick Facts
Patent No.
US 7,323,551
App. No.
10/766,317
Granted
Jan 29, 2008
Kind
B2
Abstract

The present invention relates to compositions and methods for detecting and inhibiting squamous cell carcinoma using agents that target the laminin 5 alpha 3 G4-G5 domain.

Claims (4)

1. A composition comprising a monoclonal antibody against an epitope in the human laminin 5 alpha 3 G4-5 domain, which antibody specifically binds an epitope in the human laminin 5 alpha 3 G4-5 domain lying between amino acid 1399 and amino acid 1713 of SEQ ID NO:2, and a pharmaceutically acceptable carrier.

2. A composition comprising a monoclonal antibody against an epitope in the human laminin 5 alpha 3 G4-5 domain, wherein said antibody binds to an epitope in the laminin 5 alpha 3 G4 domain lying between amino acid 1375 and amino acid 1390 of SEQ ID NO:2 and a pharmaceutically acceptable carrier.

3. A composition according to claim 1 , wherein said antibody does not bind to an epitope for a BMP-1 cleavage site within said laminin 5 alpha 3 G4-5 domain.

4. A composition comprising a monoclonal antibody against an epitope in the human laminin 5 alpha 3 G4-5 domain, wherein said antibody binds to an epitope in laminin 5 alpha 3 G4 domain lying between amino acid 1358 and amino acid 1366 of SEQ ID NO:2 and a pharmaceutically acceptable carrier.

Assignments (5)
CONFIRMATORY LICENSE Recorded Jun 2, 2011
From: STANFORD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 026381/0332 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 7, 2009
From: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; THE DEPARTMENT OF VETERANS AFFAIRS
Reel/Frame 022516/0161 →
EXECUTIVE ORDER 9424, CONFIRMATORY LICENSE Recorded Nov 4, 2008
From: STANFORD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 021781/0729 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 3, 2005
From: MARINKOVICH, PETER
To: BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY, THE
Reel/Frame 016227/0118 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2004
From: MARINKOVICH, M. PETER
To: STANFORD UNIVERSITY
Reel/Frame 015683/0241 →
Continuity (1)
Related Publication 20060009630A1 · Jan 12, 2006