TNP-470 species, polymer conjugates and use thereof
The present invention relates to conjugates of water-soluble polymers and o-(chloracetyl-carbamoyl) fumagillol (TNP-470) and use of those conjugates as specific intracellular carriers of the TNP-470 into tumor vessels. The present invention further relates to use of those conjugates to lower the neurotoxicity of TNP-470. Preferably, the polymer has a molecular weight in the range of 100 Da to 800 kDa. More preferably, the polymer has a molecular weight no greater than 60 kDa. Most preferably, the polymer has a molecular weight in the range of 15 kDa to 40 kDa.
1. A compound of the formula
wherein R is (CH 2 ) n R′, where n is 1 to 3, R′ is NH 2 , OH or SH, or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein R′ is (CH 2 ) 2 NH 2 .
3. A method of inhibiting angiogenesis in a mammal having undesired angiogenesis comprising administering an effective amount of the compound of claim 1 .