IP Library › Granted Patent US 7,091,185

Granted Patent B2

US 7,091,185 · App. 10/785,210 · Granted Aug 15, 2006

Periodic antimicrobial peptides

Assignee: Dow Global Technologies Inc.

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Quick Facts

Patent No.: US 7,091,185
App. No.: 10/785,210
Granted: Aug 15, 2006
Kind: B2

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Abstract

One embodiment of the invention comprises a method of producing periodic peptides, which can have antimicrobial uses, and further comprises the peptides themselves. A preferred method comprises the synthesis of simple periodic peptides made from polymerizing identical monomer units of four or fewer amino acids, wherein the minimum length of active peptide is 15 or 16 residues and wherein the minimum percentage of cationic residues is at least 25%.

Claims (116)

1. A process for inhibiting growth of a target cell comprising administering to a target cell an antimicrobial peptide comprising a periodic peptide with repeating identical monomer units of 2, 3, or 4 residues, wherein the target cell is selected from the group consisting of bacteria, yeast, and fungi, and the antimicrobial peptide is administered in an amount effective to inhibit growth of said target cell, and wherein the periodic peptide is selected from the group consisting of Seq. ID. No. 1–23, 29–61, and 64.

2. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 1.

3. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 2.

4. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 3.

5. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 4.

6. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 5.

7. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 6.

8. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 7.

9. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 8.

10. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 9.

11. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 10.

12. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 11.

13. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 12.

14. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 13.

15. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 14.

16. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 15.

17. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 16.

18. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 17.

19. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 18.

20. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 19.

21. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 20.

22. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 21.

23. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 22.

24. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 23.

25. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 29.

26. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 30.

27. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 31.

28. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 32.

29. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 33.

30. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 34.

31. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 35.

32. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 36.

33. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 37.

34. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 38.

35. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 39.

36. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 40.

37. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 41.

38. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 42.

39. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 43.

40. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 44.

41. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 45.

42. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 46.

43. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 47.

44. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 48.

45. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 49.

46. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 50.

47. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 51.

48. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 52.

49. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 53.

50. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 54.

51. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 55.

52. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 56.

53. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 57.

54. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 58.

55. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 59.

56. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 60.

57. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 61.

58. The process of claim 1 , wherein the periodic peptide is Seq. ID. No. 64.

59. A process for killing a target cell comprising administering to a target cell an antimicrobial peptide comprising a periodic peptide with repeating identical monomer units of 2, 3, or 4 residues, wherein the target cell is selected from the group consisting of bacteria, yeast, and fungi, and the antimicrobial peptide is administered in an amount effective to kill said target cell, and wherein the periodic peptide is selected from the group consisting of Seq. ID. No. 1–23, 29–61, and 64.

60. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 1.

61. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 2.

62. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 3.

63. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 4.

64. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 5.

65. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 6.

66. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 7.

67. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 8.

68. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 9.

69. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 10.

70. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 11.

71. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 12.

72. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 13.

73. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 14.

74. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 15.

75. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 16.

76. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 17.

77. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 18.

78. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 19.

79. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 20.

80. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 21.

81. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 22.

82. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 23.

83. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 29.

84. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 30.

85. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 31.

86. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 32.

87. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 33.

88. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 34.

89. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 35.

90. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 36.

91. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 37.

92. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 38.

93. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 39.

94. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 40.

95. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 41.

96. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 42.

97. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 43.

98. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 44.

99. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 45.

100. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 46.

101. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 47.

102. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 48.

103. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 49.

104. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 50.

105. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 51.

106. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 52.

107. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 53.

108. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 54.

109. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 55.

110. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 56.

111. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 57.

112. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 58.

113. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 59.

114. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 60.

115. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 61.

116. The process of claim 59 , wherein the periodic peptide is Seq. ID. No. 64.

Assignments (1)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 12, 2006

From: STROM, ROBERT M.; BRONDSEMA, PHILIP J.

To: DOW GLOBAL TECHNOLOGIES, INC.

Reel/Frame 017460/0300 →

Continuity (2)

Provisional Application 6056073700 · Feb 24, 2003

Related Publication 20050187151A1 · Aug 25, 2005