Polypeptide encoded by a nucleotide sequence of a nontypeable strain of

Assignees: Children's Hospital, Inc.; The Board of Regents of The Universoty of Oklahoma

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Quick Facts

Patent No.: US 7,241,867
App. No.: 10/795,159
Granted: Jul 10, 2007
Kind: B2

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Abstract

The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.

Claims (4)

1. An isolated polypeptide comprising the amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 663.

2. An isolated polypeptide comprising the amino acid sequence of SEQ ID NO: 664.

3. A composition comprising a polypeptide of claim 1 or 2 and a pharmaceutically acceptable carrier.

4. A method for eliciting an immune response to NTHi bacteria comprising administering an immunogenically effective dose of a polypeptide of claim 1 or 2 to a patient at risk of NTHi bacterial infection.

Assignments (4)

CHANGE OF NAME Recorded Dec 17, 2012

From: CHILDREN'S HOSPITAL, INC.

To: NATIONWIDE CHILDREN'S HOSPITAL, INC.

Reel/Frame 029481/0081 →

CONFIRMATORY LICENSE Recorded Feb 23, 2010

From: CHILDREN'S HOSPITAL (COLUMBUS)

To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT

Reel/Frame 023973/0043 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 2, 2005

From: DYER, DAVID W.

To: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA