Uses of IL-23 agonists and antagonists; related reagents
View Patent ↗Provided are methods of treatment for tumors. In particular, methods are provided for modulating activity of a cytokine molecule and its receptor.
1. A method of inhibiting tumor growth comprising contacting a tumor cell with an effective amount of a binding composition comprising an antigen-binding site of an antibody that specifically binds to a polypeptide comprising residues 1-168 of SEQ ID NO:2.
2. The method of claim 1 , wherein the tumor cell expresses IL-23.
3. The method of claim 1 , wherein the binding composition comprises:
a) a polyclonal antibody;
b) a monoclonal antibody;
c) a humanized antibody, or a fragment thereof; or
d) an Fab, Fv, or F(ab′) 2 fragment.
4. The method of claim 1 , wherein the tumor cell is:
a) a colon cancer cell;
b) an ovarian cancer cell;
c) a breast cancer cell; or
d) a melanoma cell.
5. A method of treating a subject suffering from a cancer or tumor comprising administering to the subject an effective amount of a binding composition comprising an antigen-binding site of an antibody that specifically binds to a polypeptide comprising residues 1-168 of SEQ ID NO:2.
6. The method of claim 5 , wherein the binding composition inhibits:
a) growth of the cancer or tumor;
b) cachexia;
c) anorexia; or
d) angiogenesis.
7. The method of claim 5 , wherein the binding composition comprises:
a) a polyclonal antibody;
b) a monoclonal antibody;
c) a humanized antibody, or a fragment thereof; or
d) an Fab, Fv, or F(ab′) 2 fragment.
8. The method of claim 5 , wherein the cancer or tumor is of the:
a) gastrointestinal tract;
b) respiratory tract;
c) reproductive system; or
d) endocrine system.
9. The method of claim 5 , wherein the cancer or tumor is:
a) colon cancer;
b) ovarian cancer;
c) a melanoma; or
d) breast cancer.
10. A method of inhibiting tumor growth comprising contacting a tumor cell with an effective amount of a binding composition comprising an antigen-binding site of an antibody that specifically binds to a polypeptide comprising the sequence of SEQ ID NO: 2.
11. A method of treating a subject suffering from a cancer or tumor comprising administering to the subject an effective amount of a binding composition comprising an antigen-binding site of an antibody that specifically binds to a polypeptide comprising the sequence of SEQ ID NO: 2.