Application of water and organic solvent soluble ivermectin for topical and oral use
A stable, palatable solution of Ivermectin in water is provided for the mass medication of animals. The present formulation does not require the use of benzyl alcohol and is stable indefinitely in the concentrated form and for up to 30 days when mixed with water.
1 . A pharmaceutical solution comprising Ivermectin, ethyl alcohol, and polysorbate 80, without benzyl alcohol, N-methylpyrrolidone or 2-pyrrolodone for the treatment of a broad spectrum of infestations caused by a parasite.
2 . The pharmaceutical solution of claim 1 , wherein the solution is applied topically.
3 . The pharmaceutical solution of claim 1 , wherein the solution further comprises water or an organic solvent.
4 . The pharmaceutical solution of claim 1 , wherein the solution further comprises a flavoring agent.
5 . The pharmaceutical solution of claim 1 , wherein said solution is a water based solution.
6 . The pharmaceutical solution comprising Ivermectin, isopropyl alcohol and polysorbate 80, without benzyl alcohol, N-methylpyrrolidone or 2-pyrrolodone for the treatment of a broad spectrum of infestations caused by a parasite.
7 . The pharmaceutical solution of claim 6 , wherein the solution is applied topically.
8 . The pharmaceutical solution of claim 6 , wherein the solution further comprises water or an organic solvent.
9 . The pharmaceutical solution of claim 6 , wherein the solution further comprises a flavoring agent.
10 . The pharmaceutical solution of claim 6 , wherein said solution is a water based solution.
11 . A pharmaceutical solution comprising comprising Ivermectin, without benzyl alcohol, N-methylpyrrolidone or 2-pyrrolodone, in an amount of 0.1-10% by weight of the solution, mixed with a solution of 50% propylene glycol and 50% polysorbate 80 by volume, for the treatment of infestations caused by a parasite.
12 . The pharmaceutical solution of claim 11 , wherein the solution is applied topically.
13 . The pharmaceutical solution of claim 11 , wherein the solution further comprises water or an organic solvent.
14 . The pharmaceutical solution of claim 11 , wherein the solution further comprises a flavoring agent.
15 . The pharmaceutical solution of claim 11 , wherein said solution is a water based solution.
16 . A method for preparing a stable, palatable form of Ivermectin comprising the following steps:
a. adding Ivermectin to the propylene glycol to form a mixture;
b. adding Tween 80 as a coupling agent to said mixture; and
c. stirring for 12 to 24 hours.
17 . A method as in claim 16 with the additional steps of:
d. adding a flavoring agent; and
e. mixing for 1 hour.
18 . The flavoring agent of claim 16 , wherein said flavoring agent is selected from the group consisting of cyclohexyl-sulfamic acid, saccharin (o-benzosulfimide), Aspartame (i.e., L-Aspartyl-L-phenylalanine methyl ester), and sugar.