Method for determining sepsis using pro-ANF
Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers in the diagnosis of sepsis.
1. A method for the detection of sepsis in an individual suspected of having sepsis, the method comprising:
a) obtaining a plasma or serum sample from the individual;
b) contacting said sample with an antibody specific for pro-atrial natriuretic factor (pro-ANF) and
c) determining the level of pro-ANF, wherein an increased level of pro-ANF as compared to healthy individuals is indicative of sepsis.
2. The method of claim 1 further comprising the determination of at least one other indicator of sepsis.
3. The method of claim 2 wherein said at least one other indicator is procalcitonin.
4. The method of claim 1 wherein said determination of the level of pro-ANF is carried out as an immunoassay or a precipitation assay.