Inhibitors of cyclin-dependent kinases, compositions and uses related thereto
The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.
1. A compound of the structure
or a prodrug, tautomer, pharmaceutically acceptable salt, N-oxide, or stereoisomer thereof.
2. The compound of claim 1 having the structure
3. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of claim 1 or 2 .