Fast dissolving tablet and method of preparing the same
View Patent ↗The present invention provides a method for making a fast dissolving tablet. The method includes the steps of (a) preparing a first solution containing a hydrophilic polymer and a starch; (b) preparing a second solution containing a pharmaceutically active ingredient and a surfactant; (c) blending the first and the second solution together to form a plurality of granule powders by granulation; (d) mixing the granule powders with excipients; and (e) applying a compression-molding process to form the fast dissolving tablet.
1. A method for preparing a fast dissolving tablet, comprising:
preparing a powdery first solution which comprises a hydrophilic polymer and a starch;
preparing a second solution which comprises a pharmaceutically active ingredient and a surfactant;
blending the first and second solutions to form a plurality of granule powders by a granulating process;
mixing the granule powders with at least an excipient; and
applying a compression-molding process to form the fast dissolving tablet; wherein the compression-molding process applies a pressure of about 800˜1200 lb/cm 2 , wherein the tablet has a porosity of about 30˜70%, and wherein the tablet has a disintegration time of less than 1 minute.
2. The method as claimed in claim 1 , wherein the hydrophilic polymer comprises PEG, PVP, carbopol, polysaccharide, agar, MC, or HPMC.
3. The method as claimed in claim 1 , wherein the surfactant comprises edible surfactant.
4. The method as claimed in claim 1 , wherein the surfactant comprises lecithin.
5. The method as claimed in claim 1 , wherein the solvent used in the first solution and second solution is H 2 O or ethanol.
6. The method as claimed in claim 1 , wherein the granulating process comprises dry granulation, wet granulation, fluidized bed granulation, or spray granulation.
7. The method as claimed in claim 1 , wherein the diameter of the granule powders is about 300˜500 μm.
8. The method as claimed in claim 1 , wherein the excipient is a disintegrating agent, an effervescent, a lubricant, or a sweetener.
9. The method as claimed in claim 1 , wherein the excipient comprises a saccharide, an alcohol, or a sugar alcohol.
10. The method as claimed in claim 9 , wherein the saccharide is a monosaccharide or a disaccharide.
11. The method as claimed in claim 9 , wherein the sugar alcohol is mannitol, sorbitol, xylitol, or glycerol.
12. The method as claimed in claim 1 , wherein the compression-molding process uses a speed of about 15˜20 rpm.
13. The method as claimed in claim 1 , wherein the pharmaceutically active ingredient is 5˜45% by weight of the fast dissolving tablet.
14. The method as claimed in claim 1 , wherein the starch is 20˜30% by weight of the fast dissolving tablet.
15. The method as claimed in claim 1 , wherein the hydrophilic polymer is 2˜10% by weight of the fast dissolving tablet.
16. The method as claimed in claim 1 , wherein the surfactant is 2˜10% by weight of the fast dissolving tablet.
17. The method as claimed in claim 1 , wherein the excipient is 40˜50% by weight of the fast dissolving tablet.
18. The method as claimed in claim 8 , wherein the lubricant is 1˜3% by weight of the fast dissolving tablet.