TRAP-coated bone grafts and prostheses
A composition or device suitable for orthopedic or dental implantation to bone, characterized by tartrate-resistant acid phosphatase (TRAP) adsorbed to a porous hydroxyapatite substratum.
1. A method for identifying an osteolysis-promoting tumor comprising obtaining from a subject a biopsied biological sample comprising cells from a tumor, determining the presence or amount of tartrate-resistant acid phosphatase (TRAP) in the sample, and identifying the tumor as osteolysis-promoting if TRAP is present in the biological sample.
2. A method of claim 1 wherein the presence or amount of tartrate-resistant acid phosphatase is determined by reverse transcriptase polymerase chain reaction (RT-PCR), hybridization, histochemical staining, enzyme activity determination, or immunoassay.
3. A method of claim 1 wherein the biological sample is selected from the group consisting of a serum sample, a body fluid sample, and a tumor biopsy sample.