Methods of synthesizing phosphonic compounds and compounds thereof
Described herein are methods for producing phosphonic compounds and compounds thereof.
1. A composition comprising a mixture of compounds comprising the formula IV and VII
wherein R 1 , R 2 , R 3 and R 7 are hydrogen; and
R 4 comprises a higher alkyl group, a cycloalkyl group, a heterocycloalkyl group, a heteroaryl group, a protecting group, or an aryl group substituted with one or more SO 2 R or S(O) 2 OR groups, where R is hydrogen or an alkyl group.
2. The composition of claim 1 , wherein R 4 comprises CH 2 C 6 H 4 -p-S(O) 2 OH.
3. The composition of claim 1 , wherein the higher alkyl group comprises heptyl, octyl, decyl, tetradecyl, hexadecyl, eicosyl, or tetracosyl.
4. The composition of claim 1 , wherein the cycloalkyl group comprises cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl.
5. The composition of claim 1 , wherein comprises an aryl group substituted with one or more SO 2 R or S(O) 2 OR groups, where R is hydrogen or an alkyl group.