Compositions for delivery of therapeutics into the eyes and methods for making and using same
The present invention provides for compositions for administering a therapeutically effective amount of a therapeutic component. The compositions may include an ophthalmically acceptable carrier component; a therapeutically effective amount of a therapeutic component; and a retention component which may be effective to reduce wettability, induce viscosity, increase muco-adhesion, increase meniscus height on a cornea of an eye and/or increase physical apposition to a cornea of an eye of a composition.
1. A topical ophthalmic solution for administering an anti-inflammatory to a human or animal suffering from ophthalmic inflammation, the solution consisting of:
water;
ketorolac, in a range of 0.01% to 1.0% w/v;
a retention component in an amount effective to provide the topical ophthalmic composition with a viscosity greater than human tear fluid wherein the retention component consists of a mixture of medium molecular weight carboxymethyl cellulose and high molecular weight carboxymethyl cellulose wherein the medium and high molecular weight carboxymethyl cellulose have a weight ratio between 0.25 and 4 and is present in an amount of 0.1% to 2.0% w/v;
sodium hydroxide and hydrochloric acid to adjust the pH;
sodium chloride;
a buffer; and
having a pH in a
range of about 6 to about 8.
2. The topical ophthalmic composition of claim 1 wherein the medium and high molecular weight carboxymethyl cellulose is sodium carboxymethyl cellulose.
3. A topical ophthalmic solution for administering an anti-inflammatory to a human or animal suffering from ophthalmic inflammation, the solution consisting of:
water as the carrier component;
ketorolac in the amount of 0.01% to 1.0% w/v of the solution;
0.1% to 2.0% w/v of a mixture of medium molecular weight carboxymethyl cellulose and high molecular weight carboxymethyl cellulose wherein the medium and high molecular weight carboxymethyl cellulose have a weight ratio between 0.25 and 4 and are present in an amount of 0.1% to 2.0% w/v;
sodium chloride;
a buffer;
and
sodium hydroxide and hydrochloric acid to adjust the solution to a pH in a range of about 6 to about 8.
4. A topical ophthalmic solution for treatment of pain and inflammation for ocular administration to a human consisting of:
water;
ketorolac in an amount of 0.01% to 1.0% w/v of the solution;
0.1% to 2.0% w/v of a mixture of medium molecular weight carboxymethyl cellulose and high molecular weight carboxymethyl cellulose wherein the medium and high molecular weight carboxymethyl cellulose have a weight ratio between 0.25 and 4 and is present in an amount of 0.1% to 2.0% w/v;
sodium chloride;
a buffer;
and
sodium hydroxide and hydrochloric acid to adjust the solution to a pH in a range of about 6 to about 8.
5. The solution of claim 3 wherein the sodium hydroxide and hydrochloric acid are 1 N.
6. The topical ophthalmic solution of claim 4 wherein the solution has a pH of about 6.8.