Topical formulation containing oxidative reductive potential water solution and method for using same
A topical formulation containing an oxidative reduction potential (ORP) water solution and a thickening agent that is stable for at least twenty-four hours. The invention also relates to a pharmaceutical dosage form comprising (1) a formulation for topical administration comprising an oxidative reductive potential water solution and a thickening agent and (2) a sealed container, wherein the formulation is stable for at least twenty-four hours. The invention further provides a method for treating or preventing a condition in a patient comprising topically administering to a patient a therapeutically effective amount of a formulation comprising an oxidative reductive potential solution and a thickening agent, wherein the formulation is stable for at least twenty-four hours.
1 . A formulation for topical administration comprising an oxidative reductive potential water solution and a thickening agent, wherein the formulation is stable for at least twenty-four hours.
2 . The formulation of claim 1 , wherein the pH is from about 3 to about 8 and the formulation is stable for at least one week.
3 . The formulation of claim 2 , wherein the pH is from about 6.4 to about 7.8.
4 . The formulation of claim 3 , wherein the pH is from about 7.4 to about 7.6.
5 . The formulation of claim 3 , wherein the formulation is stable for at least two months.
6 . The formulation of claim 3 , wherein the formulation is stable for at least six months.
7 . The formulation of claim 3 , wherein the formulation is stable for at least one year.
8 . The formulation of claim 3 , wherein the formulation is stable for at least three years.
9 . The formulation of claim 1 , wherein the formulation is selected from the group consisting of a lotion, gel, cream, paste, and ointment.
10 . The formulation of claim 9 , wherein the formulation is a gel.
11 . The formulation of claim 10 , wherein the formulation has a viscosity of 10,000 to 100,000 cps.
12 . The formulation of claim 10 , wherein the thickening agent is present in an amount of from about 1 mg/250 mL of the ORP water solution to about 20 mg/250 mL of the ORP water solution.
13 . The formulation of claim 10 , wherein the formulation further comprises a neutralizing agent.
14 . The formulation of claim 13 , wherein neutralizing agent is present in an amount of from about 3% to about 35% by volume, based on the volume of the ORP water solution.
15 . A gel for topical administration to a patient comprising an oxidative reductive potential water solution, a thickening agent in an amount of from about 1 mg/250 mL of the ORP water solution to about 20 mg/250 mg of the ORP water solution, and a neutralizing agent in an amount of from about 3% to about 35% by volume based on volume of the ORP water solution, wherein the formulation is stable for at least two months and has pH of about 6.4 to about 7.8.
16 . A pharmaceutical dosage form comprising (1) a formulation for topical administration comprising an oxidative reductive potential water solution and a thickening agent and (2) a sealed container, wherein-the formulation is stable for at least twenty-four hours.
17 . The dosage form of claim 16 , wherein the pH of the formulation is from about 6.4 to about 7.8.
18 . The dosage form of claim 17 , wherein the pH of the formulation is from about 7.4 to about 7.6.
19 . The dosage form of claim 18 , wherein the formulation is stable for at least six months.
20 . The dosage form of claim 19 , wherein the formulation is stable for at least one year.
21 . The dosage form of claim 16 , wherein the formulation is a lotion, gel, cream, paste, or ointment.
22 . The dosage form of claim 21 , wherein the formulation is a gel.
23 . The dosage form of claim 22 , wherein the formulation has a viscosity of 10,000 to 100,000 cps.
24 . The dosage form of claim 16 , wherein the thickening agent is present in an amount of from about 1 mg/250 mL of the ORP water solution to about 20 mg/250 mL of the ORP water solution.
25 . The dosage form of claim 16 , wherein the formulation further comprises a neutralizing agent.
26 . The dosage form of claim 25 , wherein neutralizing agent is present in an amount of from about 3% to about 35% by volume, based on the volume of the ORP water solution.
27 . A method for treating a condition in a patient comprising topically administering to a patient a therapeutically effective amount of a formulation comprising an oxidative reductive potential solution and a thickening agent, wherein the formulation is stable for at least about twenty-four hours.
28 . The method of claim 27 , wherein the formulation is a gel.
29 . The method of claim 28 , wherein the formulation further comprises a neutralizing agent.
30 . A method for promoting wound healing in a patient comprising applying to a wound a formulation comprising an oxidative reductive potential water solution and a thickening agent, wherein the formulation is administered in an amount sufficient to promote wound healing and wherein the formulation is stable for at least about twenty-four hours.
31 . The method of claim 30 , wherein the formulation is a gel.
32 . The method of claim 31 , wherein the formulation further comprises a neutralizing agent.
33 . A method for preventing a condition in a patient comprising topically administering to a patient a therapeutically effective amount of a formulation comprising an oxidative reductive potential water solution and a thickening agent, wherein the formulation is stable for at least about twenty-four hours.
34 . The method of claim 33 , wherein the formulation is a gel.
35 . The method of claim 34 , wherein the formulation further comprises a neutralizing agent.