IP Library › Granted Patent US 7,282,593
Granted Patent B2
US 7,282,593 · App. 10/918,284 · Granted Oct 16, 2007

Withanamide and withanolide compositions and method of use thereof

Assignee: Board of Trustees of Michigan State University
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Quick Facts
Patent No.
US 7,282,593
App. No.
10/918,284
Granted
Oct 16, 2007
Kind
B2
Abstract

Novel isolated and purified withanamides and withanolides are described. In particular, compounds from Withania somnifera fruit are the preferred source of the withanamides and withanolides, although they can be from other plant sources. In addition to their use as powerful antioxidants, the withanamides and withanolides can be useful for the treatment of depression, Alzheimer's Disease, obesity and migraine headaches.

Claims (11)

1. An isolated and purified withanamide of the formula:

wherein R is selected from the group consisting of:

2. The compound of claim 1 wherein R is

3. The compound of claim 1 wherein R is

4. The compound of claim 1 wherein R is

5. The compound of claim 1 wherein R is

6. The compound of claim 1 wherein R is

7. The compound of claim 1 wherein R is

8. The compound of claim 1 wherein R is

9. The compound of claim 1 wherein R is

10. An isolated and purified compound of the formula

Assignments (2)
CONFIRMATORY LICENSE Recorded Dec 27, 2011
From: MICHIGAN STATE UNIVERSITY
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 027449/0817 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 13, 2004
From: NAIR, MURALEEDHARAN G.; JAYAPRAKASAM, BOLLEDDULA
To: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
Reel/Frame 015688/0972 →
Continuity (2)
Provisional Application 6050198500 · Sep 11, 2003
Related Publication 20050059727A1 · Mar 17, 2005