Methods and compositions for inducing autoimmunity in the treatment of cancers
View Patent ↗Disclosed are methods and compositions for the prevention and treatment of cancers using lipid-carrier protein conjugate compositions for generating lipid-specific immune responses in an animal. Also disclosed are methods for making phosphatidylserine conjugate compositions and their formulation for use in a variety of pharmaceutical applications including the detection and treatment of a variety of cancers and related conditions.
1. A method for treating a cancer in a subject, comprising eliciting a phosphatidylserine specific immune response in said subject with cancer by administering an immunologically effective amount of a composition comprising a phosphatidylserine/polypeptide conjugate; wherein said phosphatidylserine is covalently coupled to said polypeptide.
2. The method of claim 1 , wherein said cancer is a lymphoma, a renal, or a bladder cancer.
3. The method of claim 1 , wherein said subject is an animal.
4. The method of claim 1 , wherein said subject is a human.
5. The method of claim 1 , wherein said composition is administered to said subject parenterally, subcutaneously, or by direct injection into a tissue site.
6. The method of claim 1 , wherein said composition further comprises a pharmaceutical excipient.
7. The method of claim 1 , wherein said polypeptide is BSA, KLH, BGG, diphtheria toxin, ovalbumin or β 2 -glycoprotein I.
8. The method of claim 7 , wherein said polypeptide is β 2 -glycoprotein I.
9. The method of claim 1 , wherein said polypeptide is BSA, KLH or ovalbumin.
10. A method for treating a cancer in a subject, comprising eliciting a phosphatidylserine specific antibody response in said subject with cancer by administering a covalently coupled phosphatidylserine/polypeptide conjugate to said subject in an amount effective to treat said cancer.
11. The method of claim 10 , wherein said cancer is a lymphoma, a renal, or a bladder cancer.
12. The method of claim 10 , wherein said subject is an animal.
13. The method of claim 10 , wherein said subject is a human.
14. The method of claim 10 , wherein said conjugate is administered to the subject parenterally, subcutaneously, or by direct injection into a tissue site.
15. The method of claim 10 , wherein said conjugate is comprised in a composition, said composition comprising a pharmaceutical excipient.
16. The method of claim 10 , wherein said polypeptide is BSA, KLH, BGG, diphtheria toxin, ovalbumin or β 2 -glycoprotein I.
17. The method of claim 16 , wherein said polypeptide is β 2 -glycoprotein I.
18. The method of claim 16 , wherein said polypeptide is ovalbumin.
19. The method of claim 16 , wherein said polypeptide is BSA or KLH.
20. A method for treating a cancer in a subject, comprising eliciting a phosphatidylserine specific antibody response in said subject with cancer by administering a covalently coupled phosphatidylserine/polypeptide conjugate to said subject in an amount effective to treat said cancer; wherein said polypeptide is BSA, KLH, ovalbumin or β 2 -glycoprotein I.