Rapid-hardening calcium phosphate cement compositions
A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders and a solution that is (1) an acidic calcium phosphate solution saturated with respect to one or more calcium phosphate compounds, (2) a concentrated acid solution, or (3) salt solutions with a cationic component other than calcium. The paste is stable, resistant to washout and will form hydroxyapatite and harden relatively rapidly to a cement.
1. A composition of matter for dental restoration and bone implants and restoration comprising:
a powdered calcium compound including one or more calcium phosphate salts selected from the group consisting of monocalcium phosphate monohydrate, monocalcium phosphate anhydrous, dicalcium phosphate anhydrous, dicalcium phosphate dihydrate, octacalcium phosphate, α-tricalcium phosphate, β-tricalcium phosphate, amorphous calcium phosphate, hydroxyapatite, tetracalcium phosphate and combinations thereof; and
an acidic calcium phosphate solution saturated with respect to monocalcium phosphate monohydrate, monocalcium phosphate anhydrous or combinations thereof.
2. The composition of claim 1 wherein the powdered calcium compound includes one or more calcium salts selected from the group consisting of calcium oxide, calcium hydroxide, calcium carbonate, calcium glycerophosphate, calcium gluconate, calcium sulfate, calcium lactate and combinations thereof.
3. The composition of claim 1 including one or more additives selected from the group consisting of medicaments, filler materials, crystal adjustors, viscosity modifiers, gelling agents, pore forming agents, resorbable and nonresorbable fibers and meshes, osteoinductive factors, bone morphogenic proteins, and other proteins.
4. The composition of claim 3 , wherein the one or more additives is a gelling agent selected from the group consisting of hydroxypropyl methyl cellulose, carboxymethyl cellulose, chitosan, chitosan derivatives, collagen, gum, gelatin, and alginate, and combinations thereof.
5. The composition of claim 3 , wherein the one or more additives is a filler material.
6. The composition of claim 3 , wherein the one or more additives is a pore forming agent.
7. The composition of claim 1 , wherein the pH of the acidic composition is initially between about 0 to about 1.9.
8. A composition of matter for dental restoration and bone implants and restoration comprising:
a powdered calcium compound including one or more calcium phosphate salts selected from the group consisting of monocalcium phosphate monohydrate, monocalcium phosphate anhydrous, dicalcium phosphate anhydrous, dicalcium phosphate dihydrate, octacalcium phosphate, α-tricalcium phosphate, β-tricalcium phosphate, amorphous calcium phosphate, hydroxyapatite, tetracalcium phosphate and combinations thereof; and
an acidic calcium phosphate solution saturated with respect to dicalcium phosphate dihydrate, dicalcium phosphate anhydrous and combinations thereof.
9. The composition of claim 8 wherein the powdered calcium compound includes one or more calcium salts selected from the group consisting of calcium oxide, calcium hydroxide, calcium carbonate, calcium glycerophosphate, calcium gluconate, calcium sulfate, calcium lactate and combinations thereof.
10. The composition of claim 8 including one or more additives selected from the group consisting of medicaments, filler materials, crystal adjustors, viscosity modifiers, gelling agents, pore forming agents, resorbable and nonresorbable fibers and meshes, osteoinductive factors, bone morphogenic proteins, and other proteins.
11. The composition of claim 10 , wherein the one or more additives is a gelling agent selected from the group consisting of hydroxypropyl methyl cellulose, carboxymethyl cellulose, chitosan, chitosan derivatives, collagen, gum, gelatin, and alginate, and combinations thereof.
12. The composition of claim 10 , wherein the one or more additives is a filler material.
13. The composition of claim 10 , wherein the one or more additives is a pore forming agent.
14. The composition of claim 1 , wherein the pH of the acidic composition is initially between about 1.9 to about 4.3.
15. A method of repairing bone and tooth defects comprising:
(a) preparing the composition of any one of claims 1 and 8 ; and
(b) filling the defect with the composition prior to hardening of the composition.
16. A calcium phosphate bone cement that self-hardens at ambient temperature and is resorbable when implanted in contact with living bone comprising the composition of any one of claims 1 and 8 .