Adsorbent for oral administration, and agent for treating or preventing renal or liver disease
An adsorbent for oral administration, characterized by comprising a spherical activated carbon prepared from a thermosetting resin as a carbon source, wherein a diameter is 0.01 to 1 mm, and a specific surface area determined by Langmuir's adsorption equation is 1000 m 2 /g or more; and an adsorbent for oral administration, characterized by comprising a surface-modified spherical activated carbon prepared from a thermosetting resin as a carbon source, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m 2 /g or more, a total amount of acidic groups is 0.40 to 1.00 meq/g, and a total amount of basic groups is 0.40 to 1.10 meq/g. The adsorbents for oral administration exhibit a useful selective adsorbability, that is, a less adsorbability of useful substances in a body, and a greater adsorbability of toxic substances.
1 . An adsorbent for oral administration, comprising a spherical activated carbon prepared from a thermosetting resin as a carbon source, wherein a diameter is 0.01 to 1 mm, and a specific surface area determined by Langmuir's adsorption equation is 1000 m 2 /g or more.
2 . The adsorbent for oral administration according to claim 1 , wherein a total amount of basic groups on the spherical activated carbon is 0.40 meq/g or more.
3 . An adsorbent for oral administration, comprising a surface-modified spherical activated carbon prepared from a thermosetting resin as a carbon source, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m 2 /g or more, a total amount of acidic groups is 0.40 to 1.00 meq/g, and a total amount of basic groups is 0.40 to 1.10 meq/g.
4 . A pharmaceutical composition for treating or preventing a renal disease, comprising the adsorbent for oral administration according to claim 1 and a pharmaceutically acceptable carrier or diluent.
5 . A pharmaceutical composition for treating or preventing a renal disease, comprising the adsorbent for oral administration according to claim 3 and a pharmaceutically acceptable carrier or diluent.
6 . A pharmaceutical composition for treating or preventing a disease bearing a relationship to or deteriorated by a uremic substance, comprising the adsorbent for oral administration according to claim 3 and a pharmaceutically acceptable carrier or diluent.
7 . A pharmaceutical composition for treating or preventing a disease bearing a relationship to or deteriorated by a uremic substance, comprising the adsorbent for oral administration according to claim 3 and a pharmaceutically acceptable carrier or diluent.
8 . A pharmaceutical composition for treating or preventing a liver disease, comprising the adsorbent for oral administration according to claim 1 and a pharmaceutically acceptable carrier or diluent.
9 . A pharmaceutical composition for treating or preventing a liver disease, comprising the adsorbent for oral administration according to claim 3 and a pharmaceutically acceptable carrier or diluent.
10 . A method for treating or preventing a renal disease, comprising administering to a subject in need thereof, the adsorbent for oral administration according to claim 1 , in an amount effective thereof.
11 . A method for treating or preventing a renal disease, comprising administering to a subject in need thereof, the adsorbent for oral administration according to claim 3 , in an amount effective thereof.
12 . A method for treating or preventing a disease bearing a relationship to or deteriorated by a uremic substance, comprising administering to a subject in need thereof, the adsorbent for oral administration according to claim 1 , in an amount effective thereof.
13 . A method for treating or preventing a disease bearing a relationship to or deteriorated by a uremic substance, comprising administering to a subject in need thereof, the adsorbent for oral administration according to claim 3 , in an amount effective thereof.
14 . A method for treating or preventing a liver disease, comprising administering to a subject in need thereof, the adsorbent for oral administration according to claim 1 , in an amount effective thereof.
15 . A method for treating or preventing a liver disease, comprising administering to a subject in need thereof, the adsorbent for oral administration according to claim 3 , in an amount effective thereof.