Granted Patent
B2
US 7,795,242 · App. 10/966,874 · Granted Sep 14, 2010
Methods and compositions for immunomodulation
Assignee:
The Brigham and Women's Hospital, Inc.
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Abstract
Novel antigens are provided herein. The antigens are associated with recognition of CD1 molecules by T cells. These antigens can be used as antigens, adjuvants or as immunomodulatory agents in a variety of therapeutic and prophylactic applications.
Claims (3)
1. A method for activating a CD1d-restricted T cell comprising an α:β T cell receptor (TCR), the method comprising:
contacting the CD1d-restricted T cell with an antigen-presenting cell (APC), wherein the APC comprises CD1 molecules, and phenyl-2,2,4,6,7-pentamethyldihydro-benzofuran-5-sulfonyl (PPBF) in vitro, thereby activating the T cell.
2. The method of claim 1 , wherein the T cell is from a subject.
Assignments (3)
CONFIRMATORY LICENSE
Recorded Apr 12, 2017
From: PARTNERS HEALTHCARE INNOVATION
To: NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR
Reel/Frame 041985/0864 →
CONFIRMATORY LICENSE
Recorded Jun 18, 2009
From: BRIGHAM AND WOMEN'S HOSPITAL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 022841/0090 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 21, 2005
From: VAN RHIJN, ILDIKO; YOUNG, DAVID C.; MOODY, D. BRANCH
To: BRIGHAM AND WOMEN'S HOSPITAL, INC.
Reel/Frame 015930/0562 →
Continuity (2)
Provisional Application
6051238300
· Oct 15, 2003