Cosmetic or dermatological preparation comprising a nutrient medium phase
A cosmetic or dermatological preparation that comprises collagen and/or a derivative thereof, chitosan and/or a derivative thereof, having a degree of acetylation of up to 50%, and glycosaminoglycan and a derivative thereof.
1 - 26 . (canceled)
27 . A cosmetic or dermatological preparation comprising
(a) at least one of collagen and a derivative thereof;
(b) at least one of chitosan and a derivative thereof, having a degree of acetylation of up to 50%; and
(c) at least one of a glycosaminoglycan and a derivative thereof.
28 . The preparation of claim 27 , wherein at least one of components (a) and (b) is of marine origin.
29 . The preparation of claim 27 , wherein at least one of components (a) and (b) is of synthetic origin.
30 . The preparation of claim 27 , wherein the collagen comprises one or more collagens of type 1, type 3, type 4 and type 5.
31 . The preparation of claim 27 , wherein the chitosan comprises chitosan obtained from at least one of crustaceans and insects.
32 . The preparation of claim 27 , wherein the chitosan comprises chitosan having a molecular weight of from 80,000 g/mol to 15,000,000 g/mol.
33 . The preparation of claim 27 , wherein the glycosaminoglycan comprises at least one of chondroitin 4-sulfate and chondroitin 6-sulfate.
34 . The preparation of claim 27 , wherein the preparation comprises components (a) to (c) in a concentration of from 0.00001% to 99% by weight, based on a total weight of the preparation.
35 . The preparation of claim 34 , wherein the preparation comprises from 0.0005% to 50% by weight of components (a) to (c).
36 . The preparation of claim 35 , wherein the preparation comprises from 0.0015% to 30% by weight of components (a) to (c).
37 . The preparation of claim 27 , wherein the preparation further comprises at least one substance selected from L-cystine, L-glutamine, hypoxanthine, L-glutamic acid, thymidine, lipoic acid, linoleic acid, L-isoleucine, putrescine 2HCl, NaCl, choline chloride, KCl, putrescine, sodium acetate, vitamin B 12 , Na 2 HPO 4 , biotin, calcium pantothenate, CaCl 2 , nicotinamide, glucose, pyridoxine HCl, sodium pyruvate, thiamine HCl, NaHCO 3 , adenine, phenol red, myo-inositol, HEPES, L-alanine, folic acid, L-arginine HCl, riboflavin, L-asparagine, L-aspartic acid, L-cysteine HCl, FeSO 4 , MnSO 4 , (NH 4 ) 6 Mo 7 O 24 , glycine, NiCl 2 , L-histidine HCl, H 2 SeO 3 , Na 2 SiO 3 , SnCl 2 , L-lysine HCl, NH 4 VO 3 , L-proline, L-threonine, L-tryptophan, L-tyrosine, L-valine, insulin human, ZnSO 4 , CoCl 2 , CuSO 4 , Na 2 SeO 3 , AlCl 3 , CrK(SO 4 ) 2 , NiCl 3 , MnCl 2 , EDTA.Na 2 , polysorbate 80, L-leucine, L-methionine, NaH 2 PO 4 , L-phenylalanine, MgCl 2 , L-serine, Fe(NO 3 ) 3 , L-tyrosine, α-biotin, D-Ca pantothenate, and pyridoxal HCl.
38 . The preparation of claim 27 , wherein the preparation comprises components (a) to (c) as at least one of a nanosponge matrix and a microsponge matrix which is reconstituted in cell culture media.
39 . The preparation of claim 27 , wherein a ratio of collagen and chitosan is 60-90% to 40-10%.
40 . The preparation of claim 39 , wherein the ratio is 75-85% to 25-15%.
41 . The preparation of claim 38 , wherein the cell culture media is selected from physiological saline solution, nutrient medium and complete medium for culturing healthy, primary body cells.
42 . The preparation of claim 41 , wherein the media are derived from culture media for primary fibroblasts and keratinocytes.
43 . The preparation of claim 41 , wherein the complete media are supplemented with serum substitutes.
44 . The preparation of claim 27 , wherein the preparation further comprises one or more skin culture media selected from one or more of DMEM/HAM's F-12 (1:1) and MCDB 153.
45 . The preparation of claim 27 , wherein the preparation further comprises a citrate buffer.
46 . The preparation of claim 27 , wherein the preparation is based on one of an aqueous gel, an O/W emulsion, a WIOIW emulsion, a W/O emulsion, a microemulsion and a cosmetic stick.
47 . The preparation of claim 27 , wherein the preparation further comprises at least one of Q10, AGR, Zn orotate, carnitine, creatine and taurine.
48 . An article which comprises the preparation of claim 27 , wherein the article is selected from a wound covering, a skin covering, a patch, a pad, a tissue and a bandage.
49 . The preparation of claim 27 , wherein the preparation is present as a constituent of a polyurethane matrix.
50 . The preparation of claim 27 , wherein the preparation is present as one of an aqueous surfactant preparation, an emulsion, an ointment, a cream, a gel, a dusting powder, a mask, a matrix bandage, a gel bandage, a foam and an aerosol preparation.
51 . A skin care method, wherein the method comprises applying to skin the preparation of claim 27 .
52 . A skin treatment method, wherein the method comprises applying to injured or diseased skin the preparation of claim 27 .
53 . A method of wound management or wound healing, wherein the method comprises applying to a wound the preparation of claim 27 .
54 . The method of claim 53 , wherein the preparation is comprised in a wound covering.
55 . The method of claim 54 , wherein the wound covering comprises a polyurethane.
56 . A method of generating a complete partial skin, wherein the method comprises applying the preparation of claim 27 to a surface of a body from which skin has been removed.
57 . A method of preventing or reducing scar tissue, wherein the method comprises applying to a wound the preparation of claim 27 .
58 . A process for preparing a cosmetic or dermatological preparation comprising at least one of collagen and a derivative thereof; at least one of chitosan and a derivative thereof, having a degree of acetylation of up to 50%; and at least one of a glycosaminoglycan and a derivative thereof;
wherein the process comprises
(a) providing a solution comprising water and at least one of collagen and a derivative thereof;
(b) adding at least one of chitosan and a derivative thereof, having a degree of acetylation of up to 50%, to the solution of (a) to form a mixture; and
(c) adding at least one of a glycosaminoglycan and a derivative thereof to the mixture of (b) to form a further mixture.
59 . The process of claim 58 , wherein the solution of (a) further comprises a cell culture medium.
60 . The process of claim 58 , wherein the glycosaminoglycan comprises at least one of chondroitin 4-sulfate and chondroitin 6-sulfate.
61 . The process of claim 58 , wherein the process further comprises (d) lyophilizing the mixture of (c) to provide an aerogel.
62 . The process of claim 61 , wherein the process further comprises converting the aerogel of (d) into a hydrogel by introducing the aerogel into one of an aqueous phase, an active ingredient phase and a culture media phase of the cosmetic or dermatological preparation.
63 . The process of claim 61 , wherein the process further comprises processing the aerogel of (d) into a polyurethane matrix.